Li Xuesong, Haeberlein Simone, Zhao Lu, Mughal Mudassar N, Zhu Tao, Liu Lu, Fang Rui, Zhou Yanqin, Zhao Junlong, Grevelding Christoph G, Hu Min
State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei, People's Republic of China.
Institute of Parasitology, BFS, Justus-Liebig-University Giessen, Giessen, Germany.
Parasitol Res. 2019 Mar;118(3):881-890. doi: 10.1007/s00436-019-06224-x. Epub 2019 Feb 7.
Schistosomiasis caused by different species of schistosome parasites is one of the most debilitating helminthic diseases of humans worldwide. For decades, chemotherapy is the main method of controlling schistosomiasis. However, the fear of drug resistance has motivated the search for alternatives. It has been demonstrated that the ABL kinase inhibitor imatinib affected the development and survival of Schistosoma mansoni in vitro; however, there is still lack of information on whether imatinib also affects other schistosome species such as Schistosoma japonicum. In the present study, the anti-schistosomal potency of imatinib on adult S. japonicum was investigated in vitro, and the results showed that imatinib had a significant impact on various physiological processes of S. japonicum adult worms. Besides its negative effects on worm motility, pairing stability, and gonad development, imatinib caused pathological changes in the gastrodermis as well as the death of the parasite. Our findings suggest that imatinib is an intriguing candidate for further development as an option to fight S. japonicum.
由不同种类血吸虫寄生虫引起的血吸虫病是全球范围内人类最具致残性的蠕虫病之一。几十年来，化疗一直是控制血吸虫病的主要方法。然而，对耐药性的担忧促使人们寻找替代方法。已经证明，ABL激酶抑制剂伊马替尼在体外会影响曼氏血吸虫的发育和存活；然而，关于伊马替尼是否也会影响其他血吸虫种类，如日本血吸虫，仍然缺乏相关信息。在本研究中，对伊马替尼对日本血吸虫成虫的抗血吸虫效力进行了体外研究，结果表明伊马替尼对日本血吸虫成虫的各种生理过程有显著影响。除了对虫体运动、配对稳定性和性腺发育有负面影响外，伊马替尼还导致了胃皮层的病理变化以及寄生虫的死亡。我们的研究结果表明，伊马替尼是作为对抗日本血吸虫的一种选择而进一步开发的一个有吸引力的候选药物。
