Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, 310014, Zhejiang, P.R. China.
Cancer Institute and Department of Pharmacology/Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Cancer Metastasis Rev. 2019 Jun;38(1-2):179-188. doi: 10.1007/s10555-019-09785-6.
The microenvironment of solid tumors is often acidic due to poor vascular perfusion, regional hypoxia, and increased glycolytic activity of tumor cells. Although acidosis is harmful to most types of cells, tumor cells seem well adapted to such harsh conditions. Moreover, overwhelming evidence indicates that tumor cells are more invasive and more aggressive in acidic conditions by a cascade of cell signaling and upregulation of oncogenic gene expression. Therefore, how extracellular acidic signals are transduced to the cytoplasm and then into the nucleus is an interesting topic to many cancer researchers. In this review, we update on the recent advances in acidosis-induced tumorigenesis through the acid-sensing ion channels (ASICs) and activation of cell signaling.
由于血管灌注不良、局部缺氧和肿瘤细胞糖酵解活性增加，实体瘤的微环境通常呈酸性。尽管酸中毒对大多数类型的细胞都有害，但肿瘤细胞似乎很好地适应了这种恶劣的条件。此外，大量证据表明，肿瘤细胞在酸性条件下通过一连串的细胞信号转导和致癌基因表达的上调，变得更具侵袭性和侵略性。因此，细胞外酸性信号如何转导到细胞质，然后进入细胞核，是许多癌症研究人员感兴趣的话题。在这篇综述中，我们更新了酸感应离子通道（ASICs）和细胞信号激活引起酸中毒诱导肿瘤发生的最新进展。
