Owosho Adepitan A, Velez Miguel, Tyburski Alexander, Hofheins John, Wiley Rashidah, Stansbury Tessie, Gbadamosi Semiu O, Ryder Jon S
College of Dental Medicine, University of New England, 716 Stevens Ave, Portland, ME, 04103, USA.
Department of Epidemiology, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL, USA.
Cancer Causes Control. 2019 Mar;30(3):291-299. doi: 10.1007/s10552-019-1136-2. Epub 2019 Feb 7.
This study examines the epidemiological trends of oropharyngeal squamous cell carcinoma (OPSCC) and oral cavity squamous cell carcinoma (OCSCC) in Northern New England.
Data were obtained from the Maine, New Hampshire and Vermont cancer registries. The age-standardized incidence rates (ASIR), age-specific incidence rates, and annual percentage changes (APC) for OPSCC and OCSCC were calculated using Joinpoint regression.
The overall ASIR for OPSCC in Northern New England increased by 54.2% from 2000 to 2013 with an increase of 61.5% and 27.3% in men and women, respectively. Overall ASIR for OCSCC, on the other hand, declined throughout 2000 to 2013 by 6% and among men by 11%. In joinpoint analyses, the overall ASIRs for OPSCC significantly increased at an APC of 3.15 from 2000 to 2013, whereas the ASIRs for OCSCC remained stable at an APC of - 0.26. In men, ASIRs for OPSCC significantly increased (APC: 3.46), while that of OCSCC remained stable at an APC of - 0.87. In women, the ASIRs remained stable for both OPSCC and OCSCC at an APC of 1.97 and 0.49, respectively. For patients in the 6th decade of life, the age-specific incidence rates for OPSCC increased significantly at an APC of 3.06, also among those in the 7th and 8th decade with a significant increase at an APC of 4.98 and 3.51 per year, respectively. There were no significant changes in the APC of patients with OCSCC with respect to age group.
The overall incidence of OPSCC is increasing in Northern New England, specifically among men. Given the etiological association between OPSCC and HPV, vaccination against HPV should be effectively encouraged among the populace. The efforts on tobacco cessation, abstinence, and alcohol abuse control should be continually expanded in order to bring about a decreasing trend in OCSCC.
本研究调查了新英格兰北部口咽鳞状细胞癌（OPSCC）和口腔鳞状细胞癌（OCSCC）的流行病学趋势。
数据来自缅因州、新罕布什尔州和佛蒙特州的癌症登记处。使用Joinpoint回归计算OPSCC和OCSCC的年龄标准化发病率（ASIR）、年龄别发病率和年度百分比变化（APC）。
2000年至2013年，新英格兰北部OPSCC的总体ASIR上升了54.2%，男性和女性分别上升了61.5%和27.3%。另一方面，2000年至2013年期间，OCSCC的总体ASIR下降了6%，男性下降了11%。在Joinpoint分析中，2000年至2013年，OPSCC的总体ASIR以3.15的APC显著上升，而OCSCC的ASIR以-0.26的APC保持稳定。在男性中，OPSCC的ASIR显著上升（APC：3.46），而OCSCC的ASIR以-0.87的APC保持稳定。在女性中，OPSCC和OCSCC的ASIR分别以1.97和0.49的APC保持稳定。对于60岁年龄段的患者，OPSCC的年龄别发病率以3.06的APC显著上升，70岁和80岁年龄段的患者每年的APC分别显著上升4.98和3.51。OCSCC患者的APC在各年龄组中没有显著变化。
新英格兰北部OPSCC的总体发病率正在上升，尤其是在男性中。鉴于OPSCC与HPV之间的病因学关联，应有效鼓励民众接种HPV疫苗。应持续加大戒烟、戒酒和控制酒精滥用的力度，以使OCSCC呈下降趋势。
