College of Dental Medicine, University of New England, 716 Stevens Ave, Portland, ME, 04103, USA.
School of Community Health Sciences, University of Nevada, Las Vegas, NV, USA.
J Community Health. 2018 Aug;43(4):731-737. doi: 10.1007/s10900-018-0477-1.
This study examines trends in age-adjusted incidence rates of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) in comparison to oral cavity proper squamous cell carcinoma (OSCC) in the population of Vermont from 1999 to 2013. Data on cases of oral and pharynx cancers diagnosed in Vermont between 1999 and 2013 were obtained from the Vermont cancer registry. The age-adjusted incidence rates and annual percentage change of HPV-related OPSCC and OSCC were calculated using Joinpoint trend analysis. Four hundred and thirty-one cases of HPV-related OPSCC were diagnosed from 1999 to 2013. Males constituted 83% (P < 0.0001) of the cases and the 6th decade of life marked the highest incidence. The overall age-adjusted incidence rates for HPV-related OPSCC significantly increased (from 2.39 to 3.86 per 100,000, P < 0.0001). In males, it significantly increased (from 3.62 to 6.93 per 100,000, P < 0.0001), while in females it remained stable (from 1.18 to 1.02 per 100,000, P = 0.28) during 1999-2013. The average rate of HPV-related OPSCC significantly increased by 4.4% annually (P = 0.004). In males the average rate significantly increased by 5.3% annually (P = 0.001) and in females the rate increased by 0.37% annually (P = 0.87). In contrast, age-adjusted overall incidence rates for OSCC significantly decreased (from 3.99 to 3.35 per 100,000, P = 0.018). The overall rate of OSCC decreased by 0.96% annually (P = 0.37) and the highest incidence of cases was in the 7th decade of life. In conclusion, there was an increasing trend of HPV-related OPSCC, specifically in males, and there appears to be a decreasing trend of OSCC in Vermont.
本研究考察了 1999 年至 2013 年间佛蒙特州人群中 HPV 相关口咽鳞状细胞癌（OPSCC）与口腔固有鳞状细胞癌（OSCC）相比的年龄调整发病率趋势。1999 年至 2013 年间在佛蒙特州诊断出的口腔和咽喉癌病例的数据来自佛蒙特州癌症登记处。使用 Joinpoint 趋势分析计算 HPV 相关 OPSCC 和 OSCC 的年龄调整发病率和年百分比变化。1999 年至 2013 年期间诊断出 431 例 HPV 相关 OPSCC。男性占病例的 83%（P<0.0001），第六个十年发病率最高。HPV 相关 OPSCC 的总体年龄调整发病率显著增加（从每 100,000 人 2.39 增加到 3.86，P<0.0001）。在男性中，它显著增加（从每 100,000 人 3.62 增加到 6.93，P<0.0001），而在女性中，在 1999 年至 2013 年期间保持稳定（从每 100,000 人 1.18 增加到 1.02，P=0.28）。HPV 相关 OPSCC 的平均发病率以每年 4.4%的速度显著增加（P=0.004）。男性的平均发病率以每年 5.3%的速度显著增加（P=0.001），而女性的发病率以每年 0.37%的速度增加（P=0.87）。相比之下，OSCC 的年龄调整总体发病率显著下降（从每 100,000 人 3.99 下降到 3.35，P=0.018）。OSCC 的总体发病率每年下降 0.96%（P=0.37），发病率最高的是第七个十年。总之，HPV 相关 OPSCC 的发病率呈上升趋势，特别是在男性中，而佛蒙特州 OSCC 的发病率似乎呈下降趋势。
