Sawadpanich Kookwan, Soison Pisit, Chunlertrith Kitti, Mairiang Pisaln, Sukeepaisarnjaroen Wattana, Sangchan Apichat, Suttichaimongkol Tanita, Foocharoen Chingching
Faculty of Medicine, Division of Gastroenterology, Department of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Faculty of Medicine, Division of Allergy-Immunology-Rheumatology, Department of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Int J Rheum Dis. 2019 Apr;22(4):695-699. doi: 10.1111/1756-185X.13495. Epub 2019 Feb 6.
Small intestinal bacterial overgrowth (SIBO) results in nutrient malabsorption and malnutrition, thereby increasing the morbidity and mortality in systemic sclerosis (SSc) patients.
To evaluate the prevalence and associated factors of SIBO in SSc patients.
A cross-sectional study was conducted between July 2015 and January 2016 in SSc patients over 18, using the glucose H /CH breath test to evaluate SIBO.
Eighty-nine SSc patients (30 male and 59 female) underwent the glucose H /CH breath test. The mean age was 54.4. Twelve participants were positive for the glucose H /CH breath test, yielding a SIBO prevalence of 13.5% (95% CI 7.2-22.4) among SSc patients. A multivariate analysis revealed that duration of disease >5 years was significantly associated with SIBO (adjusted odds ratio 9.38; 95% CI 1.09-80.47).
The prevalence of SIBO, using the glucose H /CH breath test, is not common among Thai SSc patients. However, a positive result was associated with longer duration of disease.
小肠细菌过度生长（SIBO）会导致营养吸收不良和营养不良，从而增加系统性硬化症（SSc）患者的发病率和死亡率。
评估SSc患者中SIBO的患病率及相关因素。
2015年7月至2016年1月对18岁以上的SSc患者进行了一项横断面研究，采用葡萄糖氢/甲烷呼气试验评估SIBO。
89例SSc患者（30例男性和59例女性）接受了葡萄糖氢/甲烷呼气试验。平均年龄为54.4岁。12名参与者的葡萄糖氢/甲烷呼气试验呈阳性，SSc患者中SIBO的患病率为13.5%（95%CI 7.2-22.4）。多因素分析显示，病程>5年与SIBO显著相关（校正比值比9.38；95%CI 1.09-80.47）。
在泰国SSc患者中，采用葡萄糖氢/甲烷呼气试验得出的SIBO患病率并不常见。然而，阳性结果与病程较长有关。
