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硬皮病胃肠道疾病的管理:光明与阴影

Management of scleroderma gastrointestinal disease: Lights and shadows.

作者信息

Cheah Jenice X, Khanna Dinesh, McMahan Zsuzsanna H

机构信息

Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA.

出版信息

J Scleroderma Relat Disord. 2022 Jun;7(2):85-97. doi: 10.1177/23971983221086343. Epub 2022 Apr 19.

DOI:10.1177/23971983221086343
PMID:35585948
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9109510/
Abstract

Gastrointestinal symptoms affect the great majority of patients with systemic sclerosis. Management of these complications is often challenging as any region of the gastrointestinal tract may be involved, and significant heterogeneity exists in clinical presentation, kinetics, and outcomes. Here, we highlight new findings relevant to the management of systemic sclerosis-related gastrointestinal disease (lights) and consider areas that we have yet to elucidate (shadows).

摘要

胃肠道症状影响绝大多数系统性硬化症患者。这些并发症的管理往往具有挑战性,因为胃肠道的任何区域都可能受累,并且在临床表现、动力学和结果方面存在显著异质性。在此,我们重点介绍与系统性硬化症相关胃肠道疾病管理相关的新发现(亮点),并思考我们尚未阐明的领域(阴影)。

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BMJ Open. 2021 Jun 24;11(6):e048541. doi: 10.1136/bmjopen-2020-048541.
2
Linaclotide for the treatment of refractory lower bowel manifestations of systemic sclerosis.利那洛肽用于治疗系统性硬化症的难治性下消化道表现。
BMC Gastroenterol. 2021 Apr 15;21(1):174. doi: 10.1186/s12876-021-01738-0.
3
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4
Use of vonoprazan for management of systemic sclerosis-related gastroesophageal reflux disease.伏诺拉生用于治疗系统性硬化症相关的胃食管反流病
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