中国汉族人群中多态性rs1800896和rs1800871与急性胰腺炎风险的关联：一项更新的系统评价和荟萃分析。

Association between polymorphisms rs1800896 and rs1800871 and risk of acute pancreatitis in Chinese Han population: An update systemic review and meta-analysis.

作者信息

Dong L, Zhu Y

机构信息

Department of Surgery, The Second Affiliated Hospital of Zhejiang University, Hangzhou, P.R. China.

出版信息

Niger J Clin Pract. 2019 Feb;22(2):149-153. doi: 10.4103/njcp.njcp_57_18.

DOI:10.4103/njcp.njcp_57_18

PMID:30729935

Abstract

The association between interleukin-10 (IL-10) promoter region (1082 A/G (rs1800896), 819 C/T (rs1800871)) polymorphisms, and acute pancreatitis (AP) is inconclusive in Chinese Han population. In this study, six eligible studies extracted from the databases of PubMed, Web of Science, and Cochrane Library were evaluated. The results revealed a significant association between 1082 A/G (rs1800896) polymorphism and AP risk in all these five models (AG/AA: OR = 1.19, 95% Cl = 1.02-1.40, P = 0.03; GG/AA: OR = 1.80, 95% Cl = 1.38-2.23, P = 0.01; AG+GG/AA: OR = 1.29, 95% Cl = 1.11-1.50, P = 0.01; GG/AG+AA: OR = 1.62, 95% Cl = 1.27-2.08, P = 0.01; G/A: OR = 1.29, 95% Cl = 1.15-1.45, P = 0.01). In contrast, no statistically significant association was found in all these five models for 819 C/T (rs1800871) polymorphism. In summary, IL-10 polymorphism 1082 A/G (rs1800896) could increase the risk of AP in Chinese Han population.

摘要

白细胞介素-10（IL-10）启动子区域（1082 A/G（rs1800896）、819 C/T（rs1800871））多态性与急性胰腺炎（AP）之间的关联在中国汉族人群中尚无定论。本研究评估了从PubMed、Web of Science和Cochrane图书馆数据库中提取的六项符合条件的研究。结果显示，在所有这五种模型中，1082 A/G（rs1800896）多态性与AP风险之间存在显著关联（AG/AA：OR = 1.19，95% Cl = 1.02 - 1.40，P = 0.03；GG/AA：OR = 1.80，95% Cl = 1.38 - 2.23，P = 0.01；AG+GG/AA：OR = 1.29，95% Cl = 1.11 - 1.50，P = 0.01；GG/AG+AA：OR = 1.62，95% Cl = 1.27 - 2.08，P = 0.01；G/A：OR = 1.29，95% Cl = 1.15 - 1.45，P = 0.01）。相比之下，在所有这五种模型中，819 C/T（rs1800871）多态性均未发现有统计学意义的关联。总之，IL-10多态性1082 A/G（rs1800896）可能会增加中国汉族人群患AP的风险。