Natural Product Chemistry & Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, 176061, HP, India.
Academy of Scientific & Innovative Research, New Delhi, 110025, India.
Chemistry. 2019 Mar 15;25(16):4067-4071. doi: 10.1002/chem.201900271. Epub 2019 Feb 22.
Polystyrene-supported palladium (Pd@PS) nanoparticles (NPs) have been used to catalyze the aminocarbonylation of aryl halides with amines using oxalic acid as a CO source for the first-time for the synthesis of amides. Furthermore, o-iodoacetophenones participated in amidation and cyclization reactions to give isoindolinones in a single step following a concerted approach. Oxalic acid has been used as a safe, environmentally benign and operationally simple ex situ sustainable CO source under double-layer-vial (DLV) system for different aminocarbonylation reactions. Catalyst stability under a CO environment is a challenging task, however, Pd@PS was found to be recyclable and applicable for a vast substrate scope avoiding regeneration steps. Easy handling of oxalic acid, additive and base-free CO generation, catalyst stability and effortless catalyst separation from the reaction mixture by filtration and introduce of DLV are the added advantages to make the overall process a sustainable approach.
聚苯乙烯负载钯（Pd@PS）纳米粒子（NPs）首次被用于催化芳基卤化物与胺的氨基甲酰化反应，使用草酸作为 CO 源来合成酰胺。此外，邻碘苯乙酮参与酰胺化和环化反应，通过协同途径一步得到异吲哚啉酮。在双层瓶（DLV）系统中，草酸被用作安全、环境友好且操作简单的原位可持续 CO 源，用于不同的氨基甲酰化反应。然而，在 CO 环境下催化剂的稳定性是一个具有挑战性的任务，但 Pd@PS 被发现是可回收的，并适用于广泛的底物范围，避免了再生步骤。草酸的易于处理、无需添加试剂和碱的 CO 生成、催化剂的稳定性以及通过过滤和引入 DLV 从反应混合物中轻松分离催化剂是使整个过程成为可持续方法的附加优势。
