使用Mo(CO)作为CO源，在水中Pd/C催化芳基碘化物与邻氨基苯甲酸的氨羰基化反应
Pd/C-Catalyzed Aminocarbonylation of Aryl Iodides with Anthranils in Water Using Mo(CO) as the CO Source.
作者信息
Wang Zechao, Yin Zhiping, Wu Xiao-Feng
机构信息
Leibniz-Institut für Katalyse, Universität Rostock, Albert-Einstein-Straße 29a, 18059, Rostock, Germany.
Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou, 310018, P. R. China.
出版信息
Chemistry. 2017 Oct 26;23(60):15026-15029. doi: 10.1002/chem.201703994. Epub 2017 Oct 10.
A convenient procedure for the synthesis of N-(2-carbonylaryl)benzamides has been developed. Through Pd/C-catalyzed aminocarbonylation of anthranils with various hindered and functionalized aryl iodides, the desired amides were afforded in moderate to good yields. The protocol is advantageous due to the recyclable Pd/C catalyst, safe Mo(CO) as the solid CO source, and environmentally benign water as solvent. No inert atmosphere protection is needed.
已开发出一种合成N-(2-羰基芳基)苯甲酰胺的简便方法。通过钯/碳催化邻氨基苯甲酸与各种受阻和官能化芳基碘的氨羰基化反应，以中等至良好的产率得到所需的酰胺。该方法具有优势，因为钯/碳催化剂可循环使用，安全的钼(CO)作为固体一氧化碳源，以及环境友好的水作为溶剂。无需惰性气氛保护。
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