Department of Mechanical Engineering, University of British Columbia, 2054-6250 Applied Science Lane, Vancouver, BC, V6T 1Z4, Canada.
Centre for Blood Research, Life Sciences Centre, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.
Biotechniques. 2019 Jan;66(1):40-53. doi: 10.2144/btn-2018-0083.
Photo-crosslinkable hydrogels have recently attracted significant scientific interest. Their properties can be manipulated in a spatiotemporal manner through exposure to light to achieve the desirable functionality for various biomedical applications. This review article discusses the recent advances of the most common photo-crosslinkable hydrogels, including poly(ethylene glycol) diacrylate, gelatin methacryloyl and methacrylated hyaluronic acid, for various biomedical applications. We first highlight the advantages of photopolymerization and discuss diverse photosensitive systems used for the synthesis of photo-crosslinkable hydrogels. We then introduce their synthesis methods and review their latest state of development in biomedical applications, including tissue engineering and regenerative medicine, drug delivery, cancer therapies and biosensing. Lastly, the existing challenges and future perspectives of engineering photo-crosslinkable hydrogels for biomedical applications are briefly discussed.
光交联水凝胶最近引起了科学界的极大兴趣。通过暴露在光下，可以在时空上操纵它们的性质，以实现各种生物医学应用所需的理想功能。本文综述了最常见的光交联水凝胶，包括聚乙二醇二丙烯酸酯、明胶甲基丙烯酰和甲基丙烯酰化透明质酸，在各种生物医学应用中的最新进展。我们首先强调了光聚合的优点，并讨论了用于合成光交联水凝胶的各种光敏系统。然后介绍了它们的合成方法，并综述了它们在生物医学应用中的最新发展，包括组织工程和再生医学、药物输送、癌症治疗和生物传感。最后，简要讨论了用于生物医学应用的光交联水凝胶的现有挑战和未来展望。
