Department of Hepatitis & AIDS, Pasteur Institute of Iran, Tehran, Iran.
Iranian Comprehensive Hemophilia Care Center, Tehran, Iran.
Immunotherapy. 2019 Feb;11(3):215-239. doi: 10.2217/imt-2018-0105.
Heat-shock proteins (HSPs) have been involved in different functions including chaperone activity, protein folding, apoptosis, autophagy and immunity. The HSP families have powerful effects on the stimulation of innate immune responses through Toll-like receptors and scavenger receptors. Moreover, HSP-mediated phagocytosis directly enhances the processing and presentation of internalized antigens via the endocytic pathway in adaptive immune system. These properties of HSPs have been used for development of prophylactic and therapeutic vaccines against infectious and noninfectious diseases. Several studies also demonstrated the relationship between HSPs and drug resistance as well as their use as a novel biomarker for detecting tumors in patients. The present review describes different roles of HSPs in biology and medicine especially biochemical and immunological aspects.
热休克蛋白（HSPs）参与了多种功能，包括伴侣活性、蛋白质折叠、细胞凋亡、自噬和免疫。HSP 家族通过 Toll 样受体和清道夫受体对先天免疫反应的刺激具有强大的作用。此外，热休克蛋白介导的吞噬作用通过内吞途径直接增强适应性免疫系统中内化抗原的加工和呈递。这些 HSP 的特性已被用于开发针对感染性和非传染性疾病的预防性和治疗性疫苗。一些研究还表明 HSP 与耐药性之间存在关系，以及它们作为检测患者肿瘤的新型生物标志物的用途。本综述描述了 HSP 在生物学和医学中的不同作用，特别是生化和免疫学方面。
