真皮内注射肉毒毒素后皮肤生理变化及安全性评估：一项伴有面部红斑的酒渣鼻患者面部随机、双盲、安慰剂对照、分面试验性研究。
Assessment of Skin Physiology Change and Safety After Intradermal Injections With Botulinum Toxin: A Randomized, Double-Blind, Placebo-Controlled, Split-Face Pilot Study in Rosacea Patients With Facial Erythema.
机构信息
Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.
Research Institute of Medical Science, Konkuk University, Seoul, Korea.
出版信息
Dermatol Surg. 2019 Sep;45(9):1155-1162. doi: 10.1097/DSS.0000000000001819.
BACKGROUND
Botulinum toxin (BTX) has been used cosmetically with good clinical efficacy and tolerable safety.
OBJECTIVE
This randomized, double-blind, split-face clinical study aimed to investigate the efficacy and safety of intradermal BTX in patients with rosacea.
MATERIALS AND METHODS
Twenty-four participants were enrolled and randomly given intradermal injections of BTX and normal saline in both cheeks. Clinician Erythema Assessment (CEA) score, Global Aesthetic Improvement Scale (GAIS) score, skin hydration, transepidermal water loss (TEWL), melanin content, erythema index, elasticity, and sebum secretions were evaluated at baseline and 2, 4, 8, and 12 weeks.
RESULTS
On the BTX-treated side, the CEA score significantly decreased and the GAIS score significantly increased. The erythema index decreased at Weeks 4 and 8. Skin elasticity was improved at Weeks 2 and 4 and skin hydration, at Weeks 2, 4, and 8. However, TEWL and sebum secretion did not show significant differences.
CONCLUSION
Intradermal BTX injections reduced erythema and rejuvenated the skin effectively and safely in patients with rosacea.
背景
肉毒毒素（BTX）已被广泛应用于美容领域，具有良好的临床疗效和可耐受的安全性。
目的
本随机、双盲、对照的临床研究旨在评估皮内注射 BTX 治疗酒渣鼻的疗效和安全性。
材料与方法
共纳入 24 名参与者，他们的双侧脸颊分别接受 BTX 皮内注射和生理盐水皮内注射。在基线时以及治疗后 2、4、8 和 12 周，评估临床医师红斑评估（CEA）评分、整体美学改善评分（GAIS）、皮肤水分、经表皮水分丢失（TEWL）、黑素含量、红斑指数、弹性和皮脂分泌。
结果
BTX 治疗侧的 CEA 评分显著降低，GAIS 评分显著升高。红斑指数在治疗后第 4 周和第 8 周降低。皮肤弹性在治疗后第 2 周和第 4 周改善，皮肤水分在治疗后第 2、4 和 8 周改善。然而，TEWL 和皮脂分泌没有显著差异。
结论
BTX 皮内注射能有效、安全地减轻酒渣鼻患者的红斑，使皮肤年轻化。
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