Topal Sıla Çağlayan, Tuncer Burcu Balos, Elgun Serenay, Erguder Imge, Ozmeric Nurdan
J Clin Pediatr Dent. 2019;43(2):137-143. doi: 10.17796/1053-4625-43.2.12. Epub 2019 Feb 7.
To monitor the effects of rapid maxillary expansion (RME) on bone metabolic activities during and after 3 months of retention.
Fifteen patients with a mean age of 12.9 ± 0.6 years were treated with a bonded expansion device, activated 2 turns per day. The retention period was 3 months. Clinical periodontal parameters were recorded at baseline and after retention. Gingival crevicular fluid (GCF) samples were collected from maxillary first molars from the compression sides at baseline, then at 1 and 10 days and after retention. Tension side samples were obtained at baseline and after retention. Interleukin-1beta (IL-1β), transforming growth factor beta1 (TGF-β1), prostaglandin E (PGE) and nitric oxide (NO) levels were specifically measured.
Periodontal parameters increased significantly after retention relative to baseline values. Levels of IL-1β, TGF-β1 and PGE increased on day 10, and decreased after retention on the compression side. NO levels were elevated on day 10, and remained higher after retention on the compression side. Tension side cytokine levels remained higher relative to baseline values after retention.
The results of this study indicate the importance of ongoing adaptive bone activities after 3 months of retention with RME, which should be considered questionable as an effective retention period.
监测快速上颌扩弓（RME）在保持3个月期间及之后对骨代谢活动的影响。
15名平均年龄为12.9±0.6岁的患者接受了粘结式扩弓装置治疗，每天激活2圈。保持期为3个月。在基线时和保持后记录临床牙周参数。在基线时、第1天和第10天以及保持后，从压缩侧的上颌第一磨牙采集龈沟液（GCF）样本。在基线时和保持后采集张力侧样本。具体测量白细胞介素-1β（IL-1β）、转化生长因子β1（TGF-β1）、前列腺素E（PGE）和一氧化氮（NO）水平。
与基线值相比，保持后牙周参数显著增加。IL-1β、TGF-β1和PGE水平在第10天升高，在压缩侧保持后降低。NO水平在第10天升高，在压缩侧保持后仍较高。保持后，张力侧细胞因子水平相对于基线值仍较高。
本研究结果表明，RME保持3个月后持续的适应性骨活动很重要，作为一个有效的保持期，这一点值得怀疑。
