Paip1 在胰腺癌中的血管生成和侵袭作用。
Role of Paip1 on angiogenesis and invasion in pancreatic cancer.
机构信息
Department of Pathology & Cancer Research Center, Yanbian University Medical College, Yanji 133002, China; Department of Medicine, Yanbian University Hospital, Yanbian, Jilin 133000, China.
Department of Pathology & Cancer Research Center, Yanbian University Medical College, Yanji 133002, China; Key laboratory of the Science and Technology Department of Jilin Province, Yanji 133002, China.
出版信息
Exp Cell Res. 2019 Mar 15;376(2):198-209. doi: 10.1016/j.yexcr.2019.01.017. Epub 2019 Feb 4.
Poly(A)-binding protein-interacting protein 1 (Paip1) was discovered as a modulator of translation initiation as a result of binding to PABP. Increasing evidence suggested that Paip1 has been implicated in several pathogenic roles. However, its clinical significance and underlying molecular mechanisms in Pancreatic cancer (PC) remain uncertain. In our present study, we found that Paip1 was over-expressed in human PC tissues. As well as poor survival, the over-expression of Paip1 was associated with lymph node (LN) metastasis of the PC samples analyzed. Paip1 silencing inhibits PC cell proliferation, metastasis, and angiogenesis, whereas over-expression of Paip1 produces the opposite effects. In all, we proposed that Paip1 contributes to PC progression and appears to be a valid prognostic factor of PC.
多聚（A）结合蛋白相互作用蛋白 1（Paip1）最初被发现是作为翻译起始的调节剂，通过与 PABP 结合。越来越多的证据表明，Paip1 参与了几种致病作用。然而，其在胰腺癌（PC）中的临床意义和潜在分子机制仍不确定。在本研究中，我们发现 Paip1 在人 PC 组织中过表达。与生存不良相关的是，分析的 PC 样本中 Paip1 的过表达与淋巴结（LN）转移相关。沉默 Paip1 抑制 PC 细胞增殖、转移和血管生成，而过表达 Paip1 则产生相反的效果。总之，我们提出 Paip1 有助于 PC 的进展，似乎是 PC 的一个有效的预后因素。
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