Paip1 预示着宫颈癌预后不良，并促进宫颈癌发生。
Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis.
机构信息
Department of Pathology & Cancer Research Center, Yanbian University Medical College, Yanji, China.
Key Laboratory of the Science and Technology, Department of Jilin Province, Yanji, China.
出版信息
Cancer Res Treat. 2019 Oct;51(4):1653-1665. doi: 10.4143/crt.2018.544. Epub 2019 Apr 19.
PURPOSE
This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis.
MATERIALS AND METHODS
The expression of Paip1 in normal cervical epithelial tissues and cervical cancer (CC) tissues were detected by immunohistochemistry. In vivo and in vitro assays were performed to validate effect of Paip1 on CC progression.
RESULTS
Paip1 was found to be up-regulated in CC, which was linked with shorter survival. Knockdown of Paip1 inhibited cell growth, induced apoptosis and cell cycle arrest in CC cells, whereas its overexpression reversed these effects. The in vivo tumor model confirmed the pro-tumor role of Paip1 in CC growth.
CONCLUSION
Altogether, the investigation demonstrated the clinical significance of Paip1 expression, which prompted that the up-regulated of Paip1 can presumably be a potential prognostic and progression marker for CC.
目的
本研究旨在探讨多聚（A）结合蛋白相互作用蛋白 1（Paip1）在宫颈癌发生中的作用。
材料与方法
采用免疫组织化学法检测 Paip1 在正常宫颈上皮组织和宫颈癌（CC）组织中的表达。通过体内和体外实验验证 Paip1 对 CC 进展的影响。
结果
研究发现 Paip1 在 CC 中上调，与生存时间缩短相关。CC 细胞中 Paip1 的敲低抑制细胞生长，诱导细胞凋亡和细胞周期停滞，而其过表达则逆转了这些效应。体内肿瘤模型证实了 Paip1 在 CC 生长中的促肿瘤作用。
结论
总之，本研究表明 Paip1 表达具有临床意义，提示 Paip1 的上调可能是 CC 的一个潜在预后和进展标志物。
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