Ghent Research Group on Nanomedicines, Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.
Ghent Research Group on Nanomedicines, Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.
Drug Discov Today. 2019 Aug;24(8):1483-1498. doi: 10.1016/j.drudis.2019.01.023. Epub 2019 Feb 4.
Müller cells are specialized glial cells that span the entire retina from the vitreous cavity to the subretinal space. Their functional diversity and unique radial morphology render them particularly interesting targets for new therapeutic approaches. In this review, we reflect on various possibilities for selective Müller cell targeting and describe how some of their cellular mechanisms can be used for retinal neuroprotection. Intriguingly, cross-species investigation of their properties has revealed that Müller cells also have an essential role in retinal regeneration. Although many questions regarding this subject remain, it is clear that Müller cells have unique characteristics that make them suitable targets for the prevention and treatment of numerous retinal diseases.
Müller 细胞是一种特化的神经胶质细胞，从玻璃体腔到视网膜下腔，它们跨越整个视网膜。其功能多样性和独特的放射状形态使它们成为新的治疗方法的特别有趣的靶点。在这篇综述中，我们反思了各种选择性 Müller 细胞靶向的可能性，并描述了它们的一些细胞机制如何用于视网膜神经保护。有趣的是，对其特性的跨物种研究表明， Müller 细胞在视网膜再生中也起着至关重要的作用。尽管关于这个主题还有许多问题，但很明显 Müller 细胞具有独特的特性，使它们成为预防和治疗许多视网膜疾病的合适靶点。
