Phattanarudee Siripan, Sangthong Sunisa, Bhidayasiri Roongroj
Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand,
Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Eur Neurol. 2018;80(5-6):268-276. doi: 10.1159/000496937. Epub 2019 Feb 7.
Sleep disturbance is a common problem among patients with Parkinson's disease (PD).
To investigate the prevalence of daytime somnolence and night-time sleep disturbances; to characterise the night-time sleep disturbance in patients with daytime somnolence; and to determine the correlation between daytime somnolence and night-time sleep disturbances.
One hundred and sixty patients with PD were included in the study. Each patient completed the Thai version of the Epworth Sleepiness Scale (ESS) questionnaire to evaluate excessive daytime sleepiness (EDS), and the PD Sleep Scale version-2 (PDSS-2) questionnaire to evaluate night-time sleep disturbance. Subjective sleep information and details about the presence or absence of sleep attack (SA) were also obtained from the patients.
The types of daytime somnolence found in this study were EDS, SA, and combination of EDS and SA (EDS + SA) with the prevalence rates of 22.5, 3.1 and 6.3%, respectively. The prevalence of night-time sleep disturbance was 46.9%. The most common nocturnal disturbance (82.5%) was "get up at night to pass urine". There was a significant positive correlation between the ESS score and PDSS-2 total score with a correlation coefficient of 0.16 (p = 0.043). Patients with "EDS + SA" were the most affected by nocturnal disturbances, as they represented the largest group among those patients with night-time disturbances and had the highest PDSS-2 total score (p < 0.05).
There are differences in nocturnal sleep disturbances among PD patients with different types of daytime somnolence. The significant positive correlation between the ESS and the PDSS-2 total scores suggests that night-time sleep disturbance may influence daytime somnolence.
睡眠障碍是帕金森病（PD）患者中的常见问题。
调查白天嗜睡和夜间睡眠障碍的患病率；描述白天嗜睡患者的夜间睡眠障碍特征；确定白天嗜睡与夜间睡眠障碍之间的相关性。
160例PD患者纳入本研究。每位患者完成泰国版爱泼沃斯思睡量表（ESS）问卷以评估白天过度嗜睡（EDS），并完成帕金森病睡眠量表第2版（PDSS-2）问卷以评估夜间睡眠障碍。还从患者处获取主观睡眠信息以及关于是否存在睡眠发作（SA）的详细信息。
本研究中发现的白天嗜睡类型为EDS、SA以及EDS和SA的组合（EDS + SA），患病率分别为22.5%、3.1%和6.3%。夜间睡眠障碍的患病率为46.9%。最常见的夜间干扰（82.5%）是“夜间起床排尿”。ESS评分与PDSS-2总分之间存在显著正相关，相关系数为0.16（p = 0.043）。“EDS + SA”患者受夜间干扰影响最大，因为他们在夜间有干扰的患者中占比最大且PDSS-2总分最高（p < 0.05）。
不同类型白天嗜睡的PD患者夜间睡眠障碍存在差异。ESS与PDSS-2总分之间的显著正相关表明夜间睡眠障碍可能影响白天嗜睡。
