Department of Neurology and Suzhou Clinical Research Center of Neurological Diseases, the Second Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu Province, China.
Department of Neurology, Suqian First Hospital, Suqian, China.
BMC Neurol. 2021 Apr 19;21(1):165. doi: 10.1186/s12883-021-02192-x.
The clinical characteristics of Parkinson's disease (PD) differ between men and women, and late- and early-onset patients, including motor symptoms and some nonmotor symptoms, such as cognition, anxiety, and depression.
To explore the features of excessive daytime sleepiness (EDS) and night-time sleep quality in PD patients of different sexes and age at onset (AAO).
Demographic data and clinical characteristics of 586 PD patients were collected. Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) were used to investigate the daytime drowsiness and nocturnal sleep. Multivariate logistic regression analysis was used to explore the risk factors of EDS and poor night-time sleep quality.
Sleep disorders were common in PD patients. EDS was more prominent in men than in women. There was no significant difference in ESS scores between late-onset PD (LOPD) and early-onset PD. LOPD patients had a higher probability of poor night-time sleep quality. Male sex, disease duration, and depression were risk factors for EDS. In all patients of both sexes and all AAO, depression was a risk factor for poor night-time sleep.
More attention should be paid to sleep disorders of PD patients, especially male LOPD patients. Depression is a common risk factor for EDS and poor sleep quality in PD patients.
帕金森病（PD）的临床特征在男性和女性以及发病年龄晚和早的患者之间存在差异，包括运动症状和一些非运动症状，如认知、焦虑和抑郁。
探讨不同性别和发病年龄（AAO）的 PD 患者日间嗜睡（EDS）和夜间睡眠质量的特征。
收集了 586 名 PD 患者的人口统计学数据和临床特征。使用 Epworth 嗜睡量表（ESS）和匹兹堡睡眠质量指数（PSQI）评估日间困倦和夜间睡眠。采用多变量 logistic 回归分析探讨 EDS 和夜间睡眠质量差的危险因素。
睡眠障碍在 PD 患者中很常见。与女性相比，男性 EDS 更为明显。晚发性 PD（LOPD）和早发性 PD 患者的 ESS 评分无显著差异。LOPD 患者夜间睡眠质量差的可能性更高。男性、病程和抑郁是 EDS 的危险因素。在所有男女患者和所有 AAO 中，抑郁是夜间睡眠质量差的一个危险因素。
应更加关注 PD 患者的睡眠障碍，尤其是男性 LOPD 患者。抑郁是 PD 患者 EDS 和睡眠质量差的常见危险因素。
