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基底动脉穿支动脉瘤:9例报告并文献复习

Basilar artery perforator aneurysms: Report of 9 cases and review of the literature.

作者信息

Bhogal P, AlMatter M, Hellstern V, Pérez M Aguilar, Lehmberg J, Ganslandt O, Bäzner H, Henkes H

机构信息

Department of Interventional Neuroradiology, The Royal London Hospital, London, UK.

Neuroradiologische Klinik, Neurozentrum, Klinikum Stuttgart, Germany.

出版信息

J Clin Neurosci. 2019 May;63:122-129. doi: 10.1016/j.jocn.2019.01.026. Epub 2019 Feb 4.

DOI:10.1016/j.jocn.2019.01.026
PMID:30732987
Abstract

Basilar perforator artery aneurysms (BAPA's) are an under-recognised cause of sub-arachnoid haemorrhage (SAH). We present our single centre experience of BAPA's and review of the literature. We performed a retrospective review of our prospectively maintained database to identify all BAPA's that presented acute SAH between February 2009 and February 2018. We identified 9 patients (male = 7), each with a single aneurysm, and average age 55 ± 9.7 years. All aneurysms were small, 2.1 ± 0.5 mm (range 1-3 mm). Three aneurysms were not detected on initial angiography. Six aneurysms were treated with flow diversion, 3 were managed conservatively. No repeat haemorrhage occurred in the flow diverted patients. One patient treated conservatively suffered a repeat haemorrhage and died (mRS 6). Follow up imaging (n = 7), at average 5.6 months (range 3-12 months), showed complete occlusion in all the flow-diverted aneurysms and no change in one conservatively managed patient. There was no evidence of perforator infarction on the follow-up post treatment imaging. Clinical follow-up data was available in 8 patients, 6 of whom (75%) had a good outcome (mRS ≤ 2). A high index of suspicion is required to diagnose BAPA. Flow diversion can be used to treat BAPA's with acceptable risk of perforator infarction and low risk of repeat haemorrhage.

摘要

基底动脉穿支动脉瘤(BAPA)是蛛网膜下腔出血(SAH)的一个未被充分认识的病因。我们介绍我们单中心关于BAPA的经验并对文献进行综述。我们对前瞻性维护的数据库进行回顾性分析,以确定2009年2月至2018年2月期间所有表现为急性SAH的BAPA。我们确定了9例患者(男性7例),每例患者有一个单一动脉瘤,平均年龄55±9.7岁。所有动脉瘤都很小,直径为2.1±0.5毫米(范围1 - 3毫米)。初始血管造影未检测到3个动脉瘤。6个动脉瘤采用血流导向治疗,3个采取保守治疗。血流导向治疗的患者未发生再出血。1例保守治疗的患者发生再出血并死亡(改良Rankin量表评分为6分)。平均5.6个月(范围3 - 12个月)的随访影像学检查(n = 7)显示,所有血流导向治疗的动脉瘤均完全闭塞,1例保守治疗患者无变化。治疗后随访影像学检查未发现穿支梗死的证据。8例患者有临床随访数据,其中6例(75%)预后良好(改良Rankin量表评分≤2分)。诊断BAPA需要高度怀疑。血流导向可用于治疗BAPA,其穿支梗死风险可接受且再出血风险低。

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