Bhogal P, AlMatter M, Hellstern V, Pérez M Aguilar, Lehmberg J, Ganslandt O, Bäzner H, Henkes H
Department of Interventional Neuroradiology, The Royal London Hospital, London, UK.
Neuroradiologische Klinik, Neurozentrum, Klinikum Stuttgart, Germany.
J Clin Neurosci. 2019 May;63:122-129. doi: 10.1016/j.jocn.2019.01.026. Epub 2019 Feb 4.
Basilar perforator artery aneurysms (BAPA's) are an under-recognised cause of sub-arachnoid haemorrhage (SAH). We present our single centre experience of BAPA's and review of the literature. We performed a retrospective review of our prospectively maintained database to identify all BAPA's that presented acute SAH between February 2009 and February 2018. We identified 9 patients (male = 7), each with a single aneurysm, and average age 55 ± 9.7 years. All aneurysms were small, 2.1 ± 0.5 mm (range 1-3 mm). Three aneurysms were not detected on initial angiography. Six aneurysms were treated with flow diversion, 3 were managed conservatively. No repeat haemorrhage occurred in the flow diverted patients. One patient treated conservatively suffered a repeat haemorrhage and died (mRS 6). Follow up imaging (n = 7), at average 5.6 months (range 3-12 months), showed complete occlusion in all the flow-diverted aneurysms and no change in one conservatively managed patient. There was no evidence of perforator infarction on the follow-up post treatment imaging. Clinical follow-up data was available in 8 patients, 6 of whom (75%) had a good outcome (mRS ≤ 2). A high index of suspicion is required to diagnose BAPA. Flow diversion can be used to treat BAPA's with acceptable risk of perforator infarction and low risk of repeat haemorrhage.
基底动脉穿支动脉瘤(BAPA)是蛛网膜下腔出血(SAH)的一个未被充分认识的病因。我们介绍我们单中心关于BAPA的经验并对文献进行综述。我们对前瞻性维护的数据库进行回顾性分析,以确定2009年2月至2018年2月期间所有表现为急性SAH的BAPA。我们确定了9例患者(男性7例),每例患者有一个单一动脉瘤,平均年龄55±9.7岁。所有动脉瘤都很小,直径为2.1±0.5毫米(范围1 - 3毫米)。初始血管造影未检测到3个动脉瘤。6个动脉瘤采用血流导向治疗,3个采取保守治疗。血流导向治疗的患者未发生再出血。1例保守治疗的患者发生再出血并死亡(改良Rankin量表评分为6分)。平均5.6个月(范围3 - 12个月)的随访影像学检查(n = 7)显示,所有血流导向治疗的动脉瘤均完全闭塞,1例保守治疗患者无变化。治疗后随访影像学检查未发现穿支梗死的证据。8例患者有临床随访数据,其中6例(75%)预后良好(改良Rankin量表评分≤2分)。诊断BAPA需要高度怀疑。血流导向可用于治疗BAPA,其穿支梗死风险可接受且再出血风险低。