The Helga and Walter Oppenheimer Atherosclerosis Research Center, Cardiology Division and Smidt Heart Institute at Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA, United States.
Trends Cardiovasc Med. 2019 Nov;29(8):468-472. doi: 10.1016/j.tcm.2019.01.004. Epub 2019 Jan 28.
Atherosclerotic cardiovascular disease is a leading cause of death in much of the world. Adoption of a healthy lifestyle and cholesterol lowering are the key measures used to prevent major complications of atherosclerosis. Recent data have identified a critical role for inflammation mediated through activation of both innate and adaptive immune pathways in the pathophysiology of atherosclerosis opening up opportunities for development of anti-inflammatory interventions that could supplement risk factor modification and lipid lowering as an approach to further reducing the burden of atherosclerotic cardiovascular disease.
动脉粥样硬化性心血管疾病是世界上许多地区的主要死亡原因。采用健康的生活方式和降低胆固醇是预防动脉粥样硬化主要并发症的关键措施。最近的数据表明，炎症通过先天和适应性免疫途径的激活在动脉粥样硬化的病理生理学中起着关键作用，为开发抗炎干预措施提供了机会，这些措施可以作为进一步降低动脉粥样硬化性心血管疾病负担的方法，补充危险因素的改变和降低血脂。
