Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Interdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Sci Rep. 2019 Feb 7;9(1):1664. doi: 10.1038/s41598-018-38324-6.
This family study from Oman (n = 1231) explored the heritability and genetic and environmental correlations of heart rate variability (HRV) and baroreceptor reflex sensitivity (BRS) with ambulatory and beat-to-beat blood pressure (BP). Ambulatory BP was measured for 24 hours to calculate mean values for daytime and sleep separately. Time and frequency domain HRV indices, BRS, office beat-to-beat BP, and heart rate (HR) were measured for 10 minutes at rest. SOLAR software was used to perform univariate and bivariate quantitative genetic analyses adjusting for age, age, sex, their interactions and BMI. Heritability of SBP and DBP ranged from 16.8% to 40.4% for daytime, sleeping, 24-hour and office beat-to-beat measurements. HR and BRS showed a heritability of 31.9% and 20.6%, respectively, and for HRV indices heritability ranged from 11.1% to 20.5%. All HRV measurements and BRS were found to be negatively correlated with BP, but phenotypic correlation coefficients were relatively weak; HR was positively correlated with BP. None of the genetic correlations were statistically significant while environmental factors explained most of the correlations for all HRV indices with BP. Our study found consistent but weak correlations among HRV, HR, BRS and ambulatory/office beat-to-beat BP. However, environmental rather than genetic factors contributed most to those correlations.
这项来自阿曼的家系研究（n=1231）探讨了心率变异性（HRV）和压力感受反射敏感性（BRS）的遗传性以及与动态和逐搏血压（BP）的遗传和环境相关性。通过 24 小时动态血压监测分别计算日间和睡眠时的平均血压值。在休息时测量 10 分钟的时间和频域 HRV 指数、BRS、诊室逐搏血压和心率（HR）。使用 SOLAR 软件进行单变量和双变量定量遗传分析，调整年龄、性别、年龄性别交互作用和 BMI。日间、睡眠时、24 小时和诊室逐搏 BP 的 SBP 和 DBP 的遗传度范围为 16.8%至 40.4%。HR 和 BRS 的遗传度分别为 31.9%和 20.6%，而 HRV 指数的遗传度范围为 11.1%至 20.5%。所有 HRV 测量和 BRS 均与 BP 呈负相关，但表型相关系数相对较弱；HR 与 BP 呈正相关。虽然遗传相关性没有一个具有统计学意义，但环境因素解释了大多数 HRV 指数与 BP 的相关性。我们的研究发现 HRV、HR、BRS 和动态/诊室逐搏 BP 之间存在一致但较弱的相关性。然而，环境因素而不是遗传因素对这些相关性的贡献最大。
