Albarwani Sulayma, Muñoz M Loretto, Voruganti V Saroja, Jaju Deepali, Al-Yahyaee V Saeed, Rizvi Syed G, Lopez-Alvarenga Juan C, Al-Anqoudi Zahir M, Bayoumi Riad A, Comuzzie Anthony G, Snieder Harold, Hassan Mohammed O
College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.
Twin Res Hum Genet. 2012 Dec;15(6):753-8. doi: 10.1017/thg.2012.59. Epub 2012 Sep 12.
To estimate the heritability of ambulatory blood pressure (BP), heart rate (HR), and beat-to-beat office BP and HR in an isolated, environmentally and genetically homogeneous Omani Arab population.
Ambulatory BP measurements were recorded in 1,124 subjects with a mean age of 33.8 ± 16.2 years, using the auscultatory mode of the validated Schiller ambulatory BP Monitor. Beat-to-beat BP and HR were recorded by the Task Force Monitor. Heritability was estimated using quantitative genetic analysis. This was achieved by applying the maximum-likelihood-based variance decomposition method implemented in SOLAR software.
We detected statistically significant heritability estimates for office beat-to-beat, 24-hour, daytime, and sleep HR of 0.31, 0.21, 0.20, and 0.07, respectively. Heritability estimates in the above mentioned conditions for systolic BP (SBP)/diastolic BP (DBP)/mean BP (MBP)were all significant and estimated at 0.19/0.19/0.19, 0.30/0.44/0.41, 0.28/0.38/0.39, and 0.21/0.18/0.20,respectively. Heritability estimates for 24-hour and daytime ambulatory SBP, DBP, and MBP ranged from 0.28 to 0.44, and were higher than the heritability estimates for beat-to-beat recordings and sleep periods,which were estimated within a narrow range of 0.18-0.21.
In this cohort, because shared environments are common to all, the environmental influence that occurs is primarily due to the variation in non-shared environment that is unique to the individual. We demonstrated significant heritability estimates for both beat-to-beat office and ambulatory BP and HR recordings, but 24-hour and daytime ambulatory heritabilities are higher than those from beat-to-beat resting levels and ambulatory night-time recordings.
在与世隔绝、环境和基因均一的阿曼阿拉伯人群中，评估动态血压（BP）、心率（HR）以及逐搏诊室血压和心率的遗传力。
使用经过验证的席勒动态血压监测仪的听诊模式，对1124名平均年龄为33.8±16.2岁的受试者进行动态血压测量。通过动态心电图监测仪记录逐搏血压和心率。使用定量遗传分析估计遗传力。这是通过应用SOLAR软件中基于最大似然的方差分解方法实现的。
我们检测到诊室逐搏、24小时、日间和睡眠心率的遗传力估计值具有统计学意义，分别为0.31、0.21、0.20和0.07。上述条件下收缩压（SBP）/舒张压（DBP）/平均血压（MBP）的遗传力估计值均具有显著性，分别估计为0.19/0.19/0.19、0.30/0.44/0.41、0.28/0.38/0.39和0.21/0.18/0.20。24小时和日间动态SBP、DBP和MBP的遗传力估计值范围为从0.28至0.44，高于逐搏记录和睡眠期的遗传力估计值，后者估计范围较窄，为0.18 - 0.21。
在该队列中，由于所有个体共享的环境是相同的，所发生的环境影响主要归因于个体特有的非共享环境的差异。我们证明了诊室逐搏以及动态血压和心率记录均具有显著的遗传力估计值，但24小时和日间动态遗传力高于静息水平逐搏记录和夜间动态记录的遗传力。
