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长链非编码RNA BLACAT1通过miR-150-5p/CCR2促进乳腺癌细胞增殖和转移。

Long non-coding RNA BLACAT1 promotes breast cancer cell proliferation and metastasis by miR-150-5p/CCR2.

作者信息

Hu Xiaopeng, Liu Yun, Du Yaying, Cheng Teng, Xia Wenfei

机构信息

1Department of Breast and Thyroid Surgery, Division of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030 Hubei China.

2Department of ENT, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei China.

出版信息

Cell Biosci. 2019 Jan 30;9:14. doi: 10.1186/s13578-019-0274-2. eCollection 2019.

DOI:10.1186/s13578-019-0274-2
PMID:30733855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6354401/
Abstract

BACKGROUND

Breast cancer was dangerous to women health. A growing number of evidences indicate that long non-coding RNAs (lncRNAs) have many functions in the development and progression of breast cancer and may serve as the markers of diagnosis or prognosis. BLACAT1 is one of lncRNA and the roles of it in breast cancer is not clear. In this study, it is aimed to explore the roles and molecular mechanisms of BLACAT1 in breast cancer.

RESULTS

We found BLACAT1 took part in breast cancer cell aggressive phenotype. The real-time PCR result showed that BLACAT1 was up-regulated in tumor tissues compared to adjacent normal tissues. The molecular mechanism experiments demonstrated that BLACAT1 down-regulation suppressed the proliferation and metastasis of human breast cancer cells by regulating miR-150-5p targeting CCR2. The clinical studies indicated that lack of BLACAT1 was related to tumor size, metastasis. Conclusion: The present study verified the involvement of the BLACAT1 in the mediation of cell survival and metastasis through miR-150-5p targeting CCR2 in breast cancer cells.

摘要

背景

乳腺癌对女性健康构成威胁。越来越多的证据表明，长链非编码RNA（lncRNAs）在乳腺癌的发生和发展中具有多种功能，可能作为诊断或预后的标志物。BLACAT1是一种lncRNA，其在乳腺癌中的作用尚不清楚。本研究旨在探讨BLACAT1在乳腺癌中的作用及其分子机制。

结果

我们发现BLACAT1参与了乳腺癌细胞的侵袭性表型。实时PCR结果显示，与相邻正常组织相比，BLACAT1在肿瘤组织中上调。分子机制实验表明，BLACAT1的下调通过调节miR-150-5p靶向CCR2抑制人乳腺癌细胞的增殖和转移。临床研究表明，BLACAT1的缺失与肿瘤大小、转移有关。结论：本研究证实了BLACAT1通过miR-150-5p靶向CCR2参与调节乳腺癌细胞的生存和转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813a/6354401/bc5a2473ea87/13578_2019_274_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813a/6354401/0adea1e23155/13578_2019_274_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813a/6354401/821becc5bf5c/13578_2019_274_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813a/6354401/fe976f7aca7a/13578_2019_274_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813a/6354401/82ee1c9278fa/13578_2019_274_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813a/6354401/12986d105507/13578_2019_274_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813a/6354401/bc5a2473ea87/13578_2019_274_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813a/6354401/0adea1e23155/13578_2019_274_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813a/6354401/821becc5bf5c/13578_2019_274_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813a/6354401/fe976f7aca7a/13578_2019_274_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813a/6354401/82ee1c9278fa/13578_2019_274_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813a/6354401/12986d105507/13578_2019_274_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813a/6354401/bc5a2473ea87/13578_2019_274_Fig6_HTML.jpg

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