1School of Materials Engineering, Purdue University, 701 W. Stadium Avenue, West Lafayette, IN 47907 USA.
2Department of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN 47907 USA.
Antimicrob Resist Infect Control. 2019 Jan 31;8:24. doi: 10.1186/s13756-019-0467-9. eCollection 2019.
The objective of this study was to evaluate the extent and potential mechanisms of early onset surface damage from simulated wiping typical of six-months of routine disinfection and to assess the subsequent microbial risk of surfaces damaged by disinfectants.
Eight common material surfaces were exposed to three disinfectants and a neutral cleaner (neutral cleaner, quaternary ammonium, hydrogen peroxide, sodium hypochlorite) in accelerated aging tests to simulate a long-term disinfection routine. Materials were also immersed in dilute and concentrated chemical solutions to induce surface damage. Surfaces were chemically and physically characterized to determine extent of surface damage. Bactericidal efficacy testing was performed on the Quat-based disinfectant using a modified version of EPA standard operating procedure MB-25-02.
The wiping protocol increased surface roughness for some material surfaces due to mechanical abrasion of the wiping cloth. The increased roughness did not correlate with changes in bactericidal efficacy. Chemical damage was observed for some surface-disinfectant combinations. The greatest observed effects from disinfectant exposure was in changes in wettability or water contact angle.
Early onset surface damage was observed in chemical and physical characterization methods. These high-throughput material measurement methods were effective at assessing nanoscale disinfectant-surface compatibility which may go undetected though routine macroscale testing.
本研究旨在评估模拟典型六个月日常消毒擦拭的早期表面损伤程度和潜在机制，并评估因消毒剂而受损表面的后续微生物风险。
将八种常见材料表面暴露于三种消毒剂和一种中性清洁剂（中性清洁剂、季铵盐、过氧化氢、次氯酸钠）中，进行加速老化测试以模拟长期的消毒常规。还将材料浸入稀释和浓缩的化学溶液中以诱导表面损伤。对表面进行化学和物理特性分析，以确定表面损伤的程度。使用 EPA 标准操作程序 MB-25-02 的修改版对基于季铵盐的消毒剂进行杀菌效力测试。
擦拭方案因擦拭布的机械磨损而增加了一些材料表面的粗糙度。粗糙度的增加与杀菌效力的变化无关。化学损伤在一些表面-消毒剂组合中观察到。消毒剂暴露观察到的最大影响是润湿性或水接触角的变化。
在化学和物理特性分析中观察到早期表面损伤。这些高通量的材料测量方法可有效评估纳米级消毒剂-表面相容性，而常规的宏观测试可能无法检测到这种相容性。
