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伴面神经麻痹的前庭神经鞘瘤病例的改善几率:两例报告及文献综述

Chances of Improvement in Cases of Vestibular Schwannoma Presenting with Facial Nerve Weakness: Presentation of Two Cases and Literature Review.

作者信息

Rizk Ahmed R, Mehlitz Marcus, Bettag Martin

机构信息

Department of Neurosurgery, Brüder Krankenhaus Trier, Trier, Germany.

Department of Neurosurgery, Benha University, Benha, Egypt.

出版信息

J Neurol Surg B Skull Base. 2019 Feb;80(1):40-45. doi: 10.1055/s-0038-1661414. Epub 2018 Jul 3.

DOI:10.1055/s-0038-1661414
PMID:30733899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6365238/
Abstract

Facial nerve (FN) weakness as a presenting feature in vestibular schwannoma (VS) is extremely rare. We are presenting two different cases of VS with significant facial weakness and reviewed the literature for similar cases.  We are presenting two cases of VS with significant facial weakness. The first case was a 63-year-old male patient presented with 3 weeks' history of severe left-sided facial weakness (House-Brackmann [HB] grade V) and hearing loss. Magnetic resonance imaging (MRI) of the brain showed a tumor in the left internal auditory canal. Gross total removal with anatomical and physiological FN preservation was performed through a retrosigmoid approach under neurophysiological monitoring. FN function improved postoperatively to HB grade II after 16 months. The other case was 83-year-old male patient presented with sudden left-sided hearing loss and severe facial weakness (HB grade V). MRI of the brain 2.5 years before showed a left-sided (Class-T3A) cystic VS. The tumor was asymptomatic; wait-and-scan strategy was advised by the treating neurologist. Recent MRI of the brain showed approximately three times enlargement of the tumor with brain stem compression, extensive cystic changes, and suspected intratumoral hemorrhage. Surgery was performed; the tumor was subtotally removed through a retrosigmoid approach with intraoperative FN monitoring. The FN was anatomically preserved; however, physiological preservation was not possible. Severe facial weakness with incomplete lid closure persisted postoperatively.  Surgical treatment could be offered to cases of suspected VS presenting with facial weakness, as these cases may still have a chance for improvement especially in laterally located tumors.

摘要

面神经(FN)麻痹作为前庭神经鞘瘤(VS)的首发症状极为罕见。我们报告了两例伴有明显面部麻痹的VS病例,并回顾了相关文献以查找类似病例。

我们报告了两例伴有明显面部麻痹的VS病例。第一例是一名63岁男性患者,有3周严重左侧面部麻痹(House-Brackmann [HB]分级V级)和听力丧失病史。脑部磁共振成像(MRI)显示左侧内耳道有肿瘤。在神经生理监测下通过乙状窦后入路进行了肿瘤全切并保留了FN的解剖结构和生理功能。术后16个月FN功能改善至HB分级II级。另一例是一名83岁男性患者,突发左侧听力丧失和严重面部麻痹(HB分级V级)。2.5年前的脑部MRI显示左侧(T3A类)囊性VS。肿瘤无症状,主治神经科医生建议采取观察等待策略。近期脑部MRI显示肿瘤增大了约三倍,压迫脑干,有广泛的囊性改变,并怀疑有瘤内出血。进行了手术;通过乙状窦后入路在术中FN监测下对肿瘤进行了次全切除。FN在解剖学上得以保留;然而,无法实现生理功能的保留。术后仍持续存在严重面部麻痹且眼睑闭合不全。

对于疑似伴有面部麻痹的VS病例可提供手术治疗,因为这些病例尤其是位于外侧的肿瘤仍可能有改善的机会。

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本文引用的文献

1
Intracanalicular vestibular schwannomas presenting with facial nerve paralysis.表现为面神经麻痹的管内型前庭神经鞘瘤。
Acta Neurochir (Wien). 2018 Apr;160(4):689-693. doi: 10.1007/s00701-018-3498-8. Epub 2018 Feb 26.
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Clinically significant intratumoral hemorrhage in patients with vestibular schwannoma.前庭神经鞘瘤患者的具有临床意义的瘤内出血
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[The management of facial nerve tumors involving the internal auditory canal].[累及内耳道的面神经肿瘤的管理]
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1235-8.
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Cystic vestibular schwannomas: surgical considerations and outcomes.囊性前庭神经鞘瘤:手术考量与结果
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The peculiar cystic vestibular schwannoma: a single-center experience.特殊的囊性前庭神经鞘瘤:单中心经验
World Neurosurg. 2014 Dec;82(6):1271-5. doi: 10.1016/j.wneu.2014.07.011. Epub 2014 Jul 18.
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Small vestibular schwannomas presenting with facial nerve palsy.表现为面神经瘫痪的小前庭神经鞘瘤。
Otol Neurotol. 2014 Jun;35(5):895-8. doi: 10.1097/MAO.0000000000000291.
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Facial nerve schwannomas of the cerebellopontine angle: the mayo clinic experience.桥小脑角区面神经鞘瘤:梅奥诊所的经验
J Neurol Surg B Skull Base. 2012 Aug;73(4):230-5. doi: 10.1055/s-0032-1312718.
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Fluid-fluid level in cystic vestibular schwannoma: a predictor of peritumoral adhesion.囊性前庭神经鞘瘤内液-液平面:与肿瘤周围黏连相关的预测因子。
J Neurosurg. 2014 Jan;120(1):197-206. doi: 10.3171/2013.6.JNS121630. Epub 2013 Jul 19.
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Hemorrhagic vestibular schwannoma: review of the literature.出血性前庭神经鞘瘤:文献回顾。
World Neurosurg. 2014 Nov;82(5):751-6. doi: 10.1016/j.wneu.2013.02.069. Epub 2013 Feb 27.
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An update on unilateral sporadic small vestibular schwannoma.单侧散发小型前庭神经鞘瘤的最新进展。
Neurosurg Focus. 2012 Sep;33(3):E1. doi: 10.3171/2012.6.FOCUS12144.