Jacob Jeffrey T, Driscoll Colin L W, Link Michael J
Department of Neurologic Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, United States.
J Neurol Surg B Skull Base. 2012 Aug;73(4):230-5. doi: 10.1055/s-0032-1312718.
Background There is often controversy regarding the optimal management for patients with facial nerve schwannomas (FNSs) of the cerebellopontine angle (CPA). Methods The clinical and radiological outcomes in 14 patients with CPA FNS were retrospectively reviewed. Results Patients underwent resection with anatomic nerve preservation (n = 3), facial-hypoglossal nerve anastomosis (n = 4), gamma knife radiosurgery (GKS) (n = 6), or observation (n = 1). A total of 83% of tumors that underwent GKS were stable or decreased in size. No patient who underwent resection showed evidence of tumor recurrence; the tumor under observation remained unchanged with normal facial function at the time of the last follow-up. Facial function was decreased in 57%, stable in 14%, and improved in 29% of those who underwent microsurgery. A total of 67% of patients who underwent GKS had stable facial function. Serviceable hearing was maintained in 50% of patients in the GKS group and 67% of the tumor resection group. Mean and median follow-up was 48 and 43 months, respectively (range, 12 to 95 months). Conclusion Observation should be the primary management when encountered with FNS of the CPA in those with good neurologic function. Microsurgery or radiosurgery may be used in those with poor facial function or tumor progression.
背景 对于小脑脑桥角(CPA)面神经鞘瘤(FNS)患者的最佳治疗方案,一直存在争议。方法 回顾性分析14例CPA FNS患者的临床和影像学结果。结果 患者接受了保留解剖神经的切除术(n = 3)、面-舌下神经吻合术(n = 4)、伽玛刀放射外科治疗(GKS)(n = 6)或观察(n = 1)。接受GKS治疗的肿瘤中,共有83%大小稳定或缩小。接受切除术的患者均未出现肿瘤复发迹象;观察期内的肿瘤在最后一次随访时保持不变,面部功能正常。接受显微手术的患者中,57%面部功能下降,14%稳定,29%改善。接受GKS治疗的患者中,共有67%面部功能稳定。GKS组50%的患者和肿瘤切除组67%的患者保留了有用听力。平均随访时间和中位随访时间分别为48个月和43个月(范围12至95个月)。结论 对于神经功能良好的CPA FNS患者,观察应作为主要治疗方法。对于面部功能差或肿瘤进展的患者,可采用显微手术或放射外科治疗。