Yoon Hee-Young, Cho Hyun-Hae, Ryu Yon Ju
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.
Department of Radiology, Ewha Womans University, College of Medicine, Seoul, Republic of Korea.
Respir Med Case Rep. 2019 Jan 17;26:215-218. doi: 10.1016/j.rmcr.2019.01.015. eCollection 2019.
Most adenovirus infections are self-limiting in immunocompetent individuals. Here, we report a case of adenovirus pneumonia in a 17-year-old immunocompetent male. He was admitted to our emergency room complaining of a febrile sense, cough, and diarrhea for four days. Crackles in the left lung and a high fever (40.7 °C) were revealed. Initial chest X-ray and computed tomography images showed consolidation in the left lung. We immediately started empirical antibiotic treatment, but his clinical symptoms and pneumonic consolidation in radiography had not improved by hospital day three. Because adenovirus was detected in his sputum using RT-PCR, he was administered Cidofovir. After 24 h of Cidofovir treatment, the symptoms and fever subsided, and the consolidation in his X-ray was significantly reduced by hospital day nine. The early administration of Cidofovir could be beneficial for the treatment of adenovirus infection in immunocompetent patients.
大多数腺病毒感染在免疫功能正常的个体中是自限性的。在此，我们报告一例17岁免疫功能正常男性的腺病毒肺炎病例。他因发热、咳嗽和腹泻四天而入住我们的急诊室。检查发现左肺有啰音且高热（40.7°C）。最初的胸部X线和计算机断层扫描图像显示左肺实变。我们立即开始经验性抗生素治疗，但到住院第三天，他的临床症状和影像学上的肺部实变并无改善。由于通过逆转录聚合酶链反应在他的痰液中检测到腺病毒，于是给他使用了西多福韦。西多福韦治疗24小时后，症状和发热消退，到住院第九天，他X线检查中的实变明显减轻。早期给予西多福韦可能有利于免疫功能正常患者的腺病毒感染治疗。
