人类疾病中腺病毒的种类：从无害到致命
The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly.
作者信息
Khanal Subrat, Ghimire Pranita, Dhamoon Amit S
机构信息
Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA.
出版信息
Biomedicines. 2018 Mar 7;6(1):30. doi: 10.3390/biomedicines6010030.
Abstract
Adenoviridae is a family of double-stranded DNA viruses that are a significant cause of upper respiratory tract infections in children and adults. Less commonly, the adenovirus family can cause a variety of gastrointestinal, ophthalmologic, genitourinary, and neurologic diseases. Most adenovirus infections are self-limited in the immunocompetent host and are treated with supportive measures. Fatal infections can occur in immunocompromised patients and less frequently in the healthy. Adenoviral vectors are being studied for novel biomedical applications including gene therapy and immunization. In this review we will focus on the spectrum of adenoviral infections in humans.
摘要
腺病毒科是一类双链DNA病毒，是儿童和成人上呼吸道感染的重要病因。较少见的是，腺病毒科可引起多种胃肠道、眼科、泌尿生殖系统和神经系统疾病。在免疫功能正常的宿主中，大多数腺病毒感染是自限性的，采用支持性措施进行治疗。免疫功能低下的患者可能发生致命感染，健康人则较少见。腺病毒载体正被用于包括基因治疗和免疫接种在内的新型生物医学应用研究。在这篇综述中，我们将重点关注人类腺病毒感染的范围。
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本文引用的文献
1
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2
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Acta Radiol. 2017 Aug;58(8):937-943. doi: 10.1177/0284185116681039. Epub 2016 Jan 1.
3
Clinical Features and Radiological Findings of Adenovirus Pneumonia Associated with Progression to Acute Respiratory Distress Syndrome: A Single Center Study in 19 Adult Patients.腺病毒肺炎进展为急性呼吸窘迫综合征的临床特征及影像学表现：一项针对19例成年患者的单中心研究
Korean J Radiol. 2016 Nov-Dec;17(6):940-949. doi: 10.3348/kjr.2016.17.6.940. Epub 2016 Oct 31.
4
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