Department of Clinical Medicine, School of Medicine, Anhui University of Science and Technology, Huainan 232001, Anhui, China.
Department of Radiation Oncology, Huainan First People's Hospital, Huainan 232001, Anhui, China.
Biomed Res Int. 2019 Jan 13;2019:2628101. doi: 10.1155/2019/2628101. eCollection 2019.
To date, a series of studies were conducted to investigate the association between TLR2 (Toll-like receptor 2) Arg753Gln gene polymorphism and tuberculosis (TB). However, the results were inconsistent. This meta-analysis was performed to elucidate the roles of TLR2 Arg753Gln gene polymorphism in TB.
All available articles were searched from online databases such as PubMed, Medline, CNKI, and Wanfang. Statistical analyses were performed using the STATA12.0 (Stata Corp LP, College Station, TX, United States) software.
32 case-control studies comprising 5943 cases and 5991 controls were identified in this meta-analysis. Overall, the TLR2 Arg753Gln gene polymorphism was associated with high TB risk in allele model (A vs. G: OR=2.20, 95%CI=1.60-3.04, P≤0.01), dominant model (AA+AG vs. GG: OR=2.70, 95%CI=2.00-3.65, P≤0.01), and heterozygote model (AG vs. GG contrast: OR=2.97, 95%CI=2.39-3.69, P≤0.01). Subgroup analysis by ethnicity indicated that the A allele increased susceptibility to TB in Asian (OR=3.35, 95%CI=2.36-4.74) and Caucasian populations (OR=2.62, 95%CI=1.77-3.87), but not in African (2.08, 95%CI=0.62-2.72) or mixed populations (OR=0.76, 95%CI=0.36-1.14). Stratified analysis by sample type suggested that the A allele associated with high pulmonary tuberculosis (PTB) risks (OR=2.43, 95%CI=1.66-3.54), but not with extra pulmonary tuberculosis (EPTB) (OR=1.84, 95%CI=0.83-4.06).
this meta-analysis suggested the following: (1) TLR2 Arg753Gln polymorphism is significantly associated with high TB risk. (2) In subgroup analysis based on ethnicity, TLR2 Arg753Gln polymorphism elevates the risk of TB in Asian and Caucasian populations, but not in African or mixed populations. (3) Stratified by sample type, TLR2 Arg753Gln polymorphism is associated with increased PTB risk, but not with EPTB.
迄今为止，已有一系列研究探讨了 Toll 样受体 2（TLR2）Arg753Gln 基因多态性与结核病（TB）之间的关联。然而，结果并不一致。本荟萃分析旨在阐明 TLR2 Arg753Gln 基因多态性在 TB 中的作用。
检索 PubMed、Medline、CNKI 和万方等在线数据库中的所有可用文献。使用 STATA12.0（StataCorp LP，德克萨斯州 College Station，美国）软件进行统计分析。
本荟萃分析共纳入 32 项病例对照研究，包括 5943 例病例和 5991 例对照。总体而言，TLR2 Arg753Gln 基因多态性与 TB 高风险相关，在等位基因模型（A 对 G：OR=2.20，95%CI=1.60-3.04，P≤0.01）、显性模型（AA+AG 对 GG：OR=2.70，95%CI=2.00-3.65，P≤0.01）和杂合子模型（AG 对 GG 对比：OR=2.97，95%CI=2.39-3.69，P≤0.01）中均存在相关性。按种族亚组分析表明，A 等位基因增加了亚洲人群（OR=3.35，95%CI=2.36-4.74）和高加索人群（OR=2.62，95%CI=1.77-3.87）发生 TB 的易感性，但在非洲人群（2.08，95%CI=0.62-2.72）或混合人群（OR=0.76，95%CI=0.36-1.14）中不存在相关性。按样本类型分层分析表明，A 等位基因与高肺结核（PTB）风险相关（OR=2.43，95%CI=1.66-3.54），但与肺外结核（EPTB）无关（OR=1.84，95%CI=0.83-4.06）。
本荟萃分析表明：（1）TLR2 Arg753Gln 多态性与 TB 高风险显著相关。（2）基于种族的亚组分析表明，TLR2 Arg753Gln 多态性增加了亚洲和高加索人群发生 TB 的风险，但不增加非洲或混合人群发生 TB 的风险。（3）按样本类型分层，TLR2 Arg753Gln 多态性与增加 PTB 风险相关，与 EPTB 无关。
