一步共组装法制备用于双光子光动力治疗的光敏肽纳米颗粒。
One-step co-assembly method to fabricate photosensitive peptide nanoparticles for two-photon photodynamic therapy.
机构信息
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 North 2nd Street, Zhongguancun, 100190 Beijing, China.
出版信息
Chem Commun (Camb). 2019 Mar 12;55(22):3191-3194. doi: 10.1039/c9cc00025a.
PMID:30734038
Abstract
Peptide-based nanoparticles were employed to load and disperse hydrophobic porphyrins in a one-step co-assembly method in aqueous media. The isolated porphyrins doped within nanoparticles showed enhanced two-photon absorption ability and could effectively generate 1O2 to induce the apoptosis of cancer cells, which holds great prospects in two-photon PDT.
摘要
采用基于肽的纳米粒子，通过一步共组装方法在水介质中负载和分散疏水性卟啉。在纳米粒子中掺杂的分离卟啉表现出增强的双光子吸收能力，并能有效产生 1O2 以诱导癌细胞凋亡，在双光子 PDT 中具有广阔的前景。
Zotero 插件