卟啉功能化多孔硅纳米粒子的双光子激发用于光动力疗法。
Two-photon excitation of porphyrin-functionalized porous silicon nanoparticles for photodynamic therapy.
机构信息
Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM2-UM1, Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l'Ecole Normale, 34296, Montpellier, France.
出版信息
Adv Mater. 2014 Dec 3;26(45):7643-8. doi: 10.1002/adma.201403415. Epub 2014 Oct 17.
Porous silicon nanoparticles (pSiNPs) act as a sensitizer for the 2-photon excitation of a pendant porphyrin using NIR laser light, for imaging and photodynamic therapy. Mannose-functionalized pSiNPs can be vectorized to MCF-7 human breast cancer cells through a mannose receptor-mediated endocytosis mechanism to provide a 3-fold enhancement of the 2-photon PDT effect.
多孔硅纳米粒子 (pSiNPs) 可作为一种敏化剂，用于近红外激光激发连接在其表面的卟啉分子，从而实现成像和光动力治疗。甘露糖功能化的 pSiNPs 可以通过甘露糖受体介导的内吞作用被靶向 MCF-7 人乳腺癌细胞，从而增强 2 光子光动力治疗效果 3 倍。
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