替加环素与美罗培南拮抗作用：成功治疗产 KPC 肺炎克雷伯菌感染。
Antagonistic effect between tigecycline and meropenem: successful management of KPC-producing Klebsiella pneumoniae infection.
机构信息
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
出版信息
Infection. 2019 Jun;47(3):497-500. doi: 10.1007/s15010-019-01274-w. Epub 2019 Feb 7.
INTRODUCTION
A woman infected by carbapenem-resistant Klebsiella pneumoniae is reported in this study.
CASE REPORT
Tigecycline and meropenem combination was used, and indeed, in vitro checkerboard synergy test confirmed the antagonism between the two antibiotics. Thus, meropenem was ceased and single high-dose tigecycline was successful against the infection. Subsequent experiments showed that the isolates of the KPC-2-producing K. pneumoniae ST11 clone caused the infection.
CONCLUSION
Therefore, tigecycline and meropenem combination should be used with caution.
简介
本研究报告了一例感染碳青霉烯类耐药肺炎克雷伯菌的女性患者。
病例报告
使用替加环素和美罗培南联合治疗，体外棋盘微量稀释协同试验证实这两种抗生素存在拮抗作用。因此，停止使用美罗培南，改用单剂高剂量替加环素成功治愈了感染。后续实验表明，感染是由产 KPC-2 的肺炎克雷伯菌 ST11 克隆的分离株引起的。
结论
因此，替加环素和美罗培南联合使用时应谨慎。
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