替加环素与美罗培南之间的拮抗作用：从临床到实验室再到临床 - Suppr

Antagonistic effect between tigecycline and meropenem: from bed to bench to bed.

作者信息

Arend Lavinia, Telles João Paulo, Tuon Felipe Francisco

机构信息

Laboratory of Emerging Infectious Diseases, School of Medicine, Pontifícia Universidade Católica do Paraná, Rua Imaculada Conceição, 1155 Prado Velho, Curitiba, PR, 80215-901, Brazil.

Laboratório Central do Estado (LACEN-PR), Curitiba, PR, Brazil.

出版信息

Infection. 2020 Feb;48(1):141-142. doi: 10.1007/s15010-019-01353-y. Epub 2019 Sep 6.

DOI:10.1007/s15010-019-01353-y

PMID:31493167

Abstract

摘要

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Antagonistic effect between tigecycline and meropenem: from bed to bench to bed.替加环素与美罗培南之间的拮抗作用：从临床到实验室再到临床

Infection. 2020 Feb;48(1):141-142. doi: 10.1007/s15010-019-01353-y. Epub 2019 Sep 6.

Antagonistic effect between tigecycline and meropenem: successful management of KPC-producing Klebsiella pneumoniae infection.替加环素与美罗培南拮抗作用：成功治疗产 KPC 肺炎克雷伯菌感染。

Infection. 2019 Jun;47(3):497-500. doi: 10.1007/s15010-019-01274-w. Epub 2019 Feb 7.

Comparative serum bactericidal activity of meropenem-based combination regimens against extended-spectrum beta-lactamase and KPC-producing Klebsiella pneumoniae.比较美罗培南为基础的联合方案对产超广谱β-内酰胺酶和产 KPC 肺炎克雷伯菌的血清杀菌活性。

Eur J Clin Microbiol Infect Dis. 2019 Oct;38(10):1925-1931. doi: 10.1007/s10096-019-03628-6. Epub 2019 Jul 6.

In vitro activity of fosfomycin in combination with imipenem, meropenem, colistin and tigecycline against OXA 48-positive Klebsiella pneumoniae strains.体外研究磷霉素联合亚胺培南、美罗培南、黏菌素和替加环素对产 OXA-48 阳性肺炎克雷伯菌的活性。

Diagn Microbiol Infect Dis. 2013 Jul;76(3):335-8. doi: 10.1016/j.diagmicrobio.2013.04.004. Epub 2013 May 29.

Relationship between adverse drug reactions to antibacterial agents and the Klebsiella pneumoniae carbapenemase-producing (KPC) Klebsiella pneumoniae outbreak: insight from a pharmacovigilance study.抗菌药物不良反应与产碳青霉烯酶肺炎克雷伯菌（KPC）肺炎克雷伯菌爆发的关系：来自药物警戒研究的洞察。

BMC Pharmacol Toxicol. 2019 Nov 12;20(1):65. doi: 10.1186/s40360-019-0364-0.

[The efficacy and safety of different antimicrobial regimens in carbapenem-resistant bloodstream infections].[不同抗菌方案治疗碳青霉烯类耐药血流感染的疗效与安全性]

Zhonghua Nei Ke Za Zhi. 2019 Aug 1;58(8):566-571. doi: 10.3760/cma.j.issn.0578-1426.2019.08.004.

In vitro evaluation of different antimicrobial combinations against carbapenemase-producing Klebsiella pneumoniae: the activity of the double-carbapenem regimen is related to meropenem MIC value.体外评估不同抗菌药物组合对产碳青霉烯酶肺炎克雷伯菌的抗菌活性：双碳青霉烯方案的活性与美罗培南 MIC 值相关。

J Antimicrob Chemother. 2017 Jul 1;72(7):1981-1984. doi: 10.1093/jac/dkx084.

Triple combination of meropenem, colistin and tigecycline was bactericidal in a dynamic model despite mere additive interactions in chequerboard assays against carbapenemase-producing Klebsiella pneumoniae isolates.美罗培南、黏菌素和替加环素三联组合在针对产碳青霉烯酶肺炎克雷伯菌分离株的棋盘微量稀释法中表现出单纯相加作用，但在动态模型中仍具有杀菌作用。

J Antimicrob Chemother. 2019 Feb 1;74(2):387-394. doi: 10.1093/jac/dky422.

Activity of tigecycline alone and in combination with colistin and meropenem against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae strains by time-kill assay.替加环素单独及联合黏菌素和美罗培南对产碳青霉烯酶肠杆菌科细菌（KPC）菌株的时间杀菌试验研究。

Int J Antimicrob Agents. 2011 Mar;37(3):244-7. doi: 10.1016/j.ijantimicag.2010.10.031. Epub 2011 Jan 13.

Comparison of synergism between colistin, fosfomycin and tigecycline against extended-spectrum β-lactamase-producing Klebsiella pneumoniae isolates or with carbapenem resistance.比较黏菌素、磷霉素和替加环素对产超广谱β-内酰胺酶肺炎克雷伯菌分离株或碳青霉烯类耐药株的协同作用。

J Microbiol Immunol Infect. 2017 Dec;50(6):931-939. doi: 10.1016/j.jmii.2016.12.008. Epub 2017 Jul 6.

本文引用的文献

Infection. 2019 Jun;47(3):497-500. doi: 10.1007/s15010-019-01274-w. Epub 2019 Feb 7.

Risk factors for mortality in patients with ventilator-associated pneumonia caused by carbapenem-resistant Enterobacteriaceae.耐碳青霉烯类肠杆菌科细菌所致呼吸机相关性肺炎患者的死亡危险因素

Braz J Infect Dis. 2017 Jan-Feb;21(1):1-6. doi: 10.1016/j.bjid.2016.09.008. Epub 2016 Nov 4.

Three Dimensional Checkerboard Synergy Analysis of Colistin, Meropenem, Tigecycline against Multidrug-Resistant Clinical Klebsiella pneumonia Isolates.多粘菌素、美罗培南、替加环素对耐多药临床肺炎克雷伯菌分离株的三维棋盘协同分析

PLoS One. 2015 Jun 11;10(6):e0126479. doi: 10.1371/journal.pone.0126479. eCollection 2015.

Activity of antimicrobial combinations against KPC-2-producing Klebsiella pneumoniae in a rat model and time-kill assay.抗菌药物联合对大鼠模型中产KPC-2肺炎克雷伯菌的活性及时间杀菌试验

Antimicrob Agents Chemother. 2015 Jul;59(7):4301-4. doi: 10.1128/AAC.00323-15. Epub 2015 Apr 20.

Efficacy of tigecycline, polymyxin, gentamicin, meropenem and associations in experimental Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae non-lethal sepsis.替加环素、多黏菌素、庆大霉素、美罗培南及其联合用药在实验性产肺炎克雷伯菌碳青霉烯酶肺炎克雷伯菌非致死性败血症中的疗效。

Braz J Infect Dis. 2014 Sep-Oct;18(5):574-5. doi: 10.1016/j.bjid.2014.05.003. Epub 2014 Jun 5.

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Antagonistic effect between tigecycline and meropenem: from bed to bench to bed.

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