Chaouat G, Menu E, Bustany P, Rebut-Bonneton C, Szekeres-Bartho J, Wegmann T G
Unité 262 INSERM, Clinique Universitaire Baudelocque, Paris, France.
Reprod Nutr Dev (1980). 1988;28(6B):1587-98.
Present knowledge of the alloantigenic status of the placenta, which makes it a natural semi-allogeneic allograft is briefly surveyed. The systemic immunoregulatory mechanisms operating during normal allopregnancy which are not a prerequisite for a successful pregnancy are recalled. The placenta--dependent local mechanisms, e.g. trophoblast dependent decidual suppressor cells, factor mediated and factor independent resistance to cell mediated lysis, are surveyed as well as some of the mechanisms of action of trophoblast regulatory factors, namely suppressor cell induction and inhibition of IL-2 dependent cell growth/activation. The main feature of the CBA x DBA/2 model of spontaneous abortions in mice, and its prevention by anti Balb/c leukocyte immunisation are described. It was shown that anti-T cell depletion prevents the anti-abortive effects of immunisation. Such a treatment is also able to restore normal placental weight in auto-immune MRL lpr mice, which are known to display excess seric CSF beta-like activity (CSFs being in vitro efficient growth factors for trophoblasts). Transfer of such cells into the MHC compatible CBA/J prevents resorbtions upon a subsequent mating with DBA/2. Thus, direct effects of CSFs beta 1 and beta 2 as anti abortifacient (IL3 and GM CSF) are described together with the abortificacient effects of TNFs and NKs activators.
本文简要综述了目前对胎盘同种异体抗原状态的认识，胎盘是一种天然的半同种异体移植器官。回顾了正常同种异体妊娠期间起作用的全身免疫调节机制，这些机制并非成功妊娠的先决条件。还探讨了胎盘依赖的局部机制，例如滋养层依赖的蜕膜抑制细胞、因子介导和非因子依赖的对细胞介导溶解的抗性，以及滋养层调节因子的一些作用机制，即抑制细胞诱导和对IL-2依赖的细胞生长/激活的抑制。描述了CBA×DBA/2小鼠自发流产模型的主要特征，以及通过抗Balb/c白细胞免疫预防流产的方法。结果表明，抗T细胞耗竭可阻止免疫的抗流产作用。这种治疗方法还能够恢复自身免疫性MRL lpr小鼠的正常胎盘重量，已知这些小鼠血清中CSFβ样活性过高（CSF在体外是滋养层有效的生长因子）。将这些细胞转移到MHC相容的CBA/J小鼠中，可防止其在随后与DBA/2交配时发生吸收。因此，描述了CSFβ1和β2作为抗流产剂（IL3和GM CSF）的直接作用，以及TNF和NK激活剂的流产作用。
