Li Minmin, Zhang Tao, Tan Benxu, Yu Min, Zhang Binglan
a Department of Oncology , First Affiliated Hospital of Chongqing Medical University , Chongqing , China.
b Department of gastroenterology , First Affiliated Hospital of Chongqing Medical University , Chongqing , China.
Acta Otolaryngol. 2019 Feb;139(2):172-177. doi: 10.1080/00016489.2018.1542159. Epub 2019 Feb 8.
Studies have shown mixed results on the role of postoperative adjuvant radiotherapy (PORT) in surgically managed locally advanced laryngeal cancer.
The aim of this study is to review and investigate the role of PORT in patients with locally advanced laryngeal cancer using meta-analysis.
Relevant studies were searched using PubMed and eligible information has been extracted. Then, meta-analysis of hazard ratio (HR) was performed to evaluate the role of PORT in locally advanced laryngeal cancer.
This meta-analysis included 7 published studies containing 2007 patients. For overall survival (OS), patients of locally advanced laryngeal cancer who were treated with PORT have a combined hazard ratio (HR) of 0.67 with 95%CI (0.56, 0.79), compared to those who were not treated with PORT, which was significantly associated with better survival. PORT was also associated with a better disease-free survival (DFS) and local control rate (LCR) in patients with locally advanced laryngeal cancer. The pooled HR and 95%CI for DFS and LCR were 0.72 (0.53, 0.99) and 0.29 (0.09, 0.99), respectively.
This study suggested that PORT could improve the survival of patients with surgically managed locally advanced laryngeal cancer.
关于术后辅助放疗（PORT）在手术治疗局部晚期喉癌中的作用，研究结果不一。
本研究旨在通过荟萃分析回顾和探讨PORT在局部晚期喉癌患者中的作用。
使用PubMed检索相关研究并提取合格信息。然后，对风险比（HR）进行荟萃分析，以评估PORT在局部晚期喉癌中的作用。
该荟萃分析纳入了7项已发表的研究，共2007例患者。对于总生存期（OS），接受PORT治疗的局部晚期喉癌患者的合并风险比（HR）为0.67，95%置信区间（CI）为（0.56，0.79），与未接受PORT治疗的患者相比，这与更好的生存率显著相关。PORT还与局部晚期喉癌患者更好的无病生存期（DFS）和局部控制率（LCR）相关。DFS和LCR的合并HR及95%CI分别为0.72（0.53，0.99）和0.29（0.09，0.99）。
本研究表明，PORT可提高手术治疗的局部晚期喉癌患者的生存率。
