Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea.
Department of Neurosurgery, School of Medicine, Chosun University, Gwangju, Republic of Korea.
Am J Trop Med Hyg. 2019 Feb;100(2):399-404. doi: 10.4269/ajtmh.17-0565.
This study compared the frequency of abnormal electrocardiogram (ECG) types between scrub typhus patient group and age- and gender-matched health checkup group and their associations with disease severity in scrub typhus patient. Demographic characteristics and ECG and laboratory findings of patients with scrub typhus admitted to Chosun University Hospital, and normal subjects visiting the hospital for health checkup from January 2008 to December 2012 were retrospectively studied. Electrocardiogram abnormalities at admission were observed in 72 of 165 (43.6%) scrub typhus confirmed patients. The following ECG abnormalities were observed: arrhythmic group (31 cases, 18.8%), ischemic change group (25 cases, 15.1%), prolonged QT group (32 cases, 19.4%).Compared with the age and gender-matched health checkup group, ECG abnormalities were more commonly observed in scrub typhus patient group (13.9% versus 43.6%, < 0.001). In addition, when compared with the normal ECG group, scrub typhus in the abnormal ECG group showed greater disease severity and this phenomenon was particularly prominent in the prolonged QT group. Based on our study prolonged QT observed in approximately 20% of patients with scrub typhus, clinicians should pay additional attention to drugs that affect QT interval.
本研究比较了恙虫病患者组与年龄和性别匹配的健康体检组之间异常心电图（ECG）类型的频率及其与恙虫病患者疾病严重程度的关系。回顾性研究了 2008 年 1 月至 2012 年 12 月期间，在朝鲜大学医院住院的恙虫病患者和因健康检查而到医院就诊的正常受试者的人口统计学特征、心电图和实验室检查结果。在 165 例确诊为恙虫病的患者中，有 72 例（43.6%）在入院时出现心电图异常。观察到的心电图异常包括：心律失常组（31 例，18.8%）、缺血性改变组（25 例，15.1%）、QT 间期延长组（32 例，19.4%）。与年龄和性别匹配的健康体检组相比，恙虫病患者组心电图异常更为常见（13.9%比 43.6%，<0.001）。此外，与正常心电图组相比，异常心电图组的恙虫病患者疾病严重程度更高，这种现象在 QT 间期延长组尤为明显。根据我们的研究，大约 20%的恙虫病患者出现 QT 间期延长，临床医生应特别注意影响 QT 间期的药物。
