College of Chemistry, Sichuan University, Chengdu, 610064, China.
Analytical & Testing Center, Sichuan University, Chengdu, 610064, China.
Anal Bioanal Chem. 2019 Jul;411(19):4415-4423. doi: 10.1007/s00216-019-01605-8. Epub 2019 Feb 8.
Recently, photosensitized oxidation has been explored in many fields of research and applications, such as photodynamic therapy (PDT) and photodynamic antimicrobial chemotherapy (PACT). Although the photosensitized generation of ROS features emerging applications, controllable management of the photosensitization process is still sometimes problematic. DNA has long been considered the carrier for genetic information. With the in-depth study of the chemical properties of DNA, the molecular function of DNA is gradually witnessed by the scientific community. Undoubtedly, the selective recognition nature of DNA endows them excellent candidate modulators for photosensitized oxidation. According to current research, reports on DNA regulation of photosensitized oxidation can be roughly divided into two categories in principle: P-Q quenching pair-switched photosensitization and host-guest interaction-switched photosensitization. In this review, the development status of these two analytical methods will be summarized, and the future development direction of DNA-modulated photosensitization in biosensing and environmental monitoring will also be prospected.
近年来，光动力氧化已在许多研究和应用领域得到了探索，如光动力疗法（PDT）和光动力抗菌化疗（PACT）。尽管光敏剂产生 ROS 的特性具有新兴的应用，但光敏化过程的可控管理有时仍然存在问题。DNA 长期以来一直被认为是遗传信息的载体。随着对 DNA 化学性质的深入研究，科学界逐渐见证了 DNA 的分子功能。毫无疑问，DNA 的选择性识别特性使它们成为光敏氧化的优秀候选调节剂。根据目前的研究，关于 DNA 调节光敏氧化的报告大致可以分为两类：P-Q 猝灭对开关光致氧化和主体-客体相互作用开关光致氧化。在这篇综述中，将总结这两种分析方法的发展现状，并展望 DNA 调节的光致氧化在生物传感和环境监测中的未来发展方向。
