通过完全非肽整合素选择性配体控制生物材料上的干细胞反应和骨生长。
Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands.
机构信息
Biomaterials, Biomechanics and Tissue Engineering Group, Dept. of Materials Science and Metallurgy, Universitat Politècnica de Catalunya, Barcelona, Spain.
出版信息
Biomater Sci. 2019 Mar 26;7(4):1281-1285. doi: 10.1039/c8bm01466c.
PMID:30735211
Abstract
In this communication we report that anchoring αvβ3 or α5β1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successful to engineer instructive coatings for orthopedic applications.
摘要
在本通讯中，我们报告称，将锚定αvβ3 或 α5β1 整联蛋白选择性 RGD 肽模拟物与钛结合，可有效地调节间充质干细胞在体外的反应和大鼠颅骨缺损中的骨生长。我们的结果表明，这种基于分子化学的方法可成功地用于设计用于矫形应用的指导性涂层。
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