Bakhshaliev A B, Gadzhiev R F, Lan'shina O E
Ter Arkh. 1988;60(12):21-6.
A total of 50 patients with essential hypertension, I-II stages, were investigated to study changes in peripheral and intracardiac hemodynamics and myocardial contractility in moderate restriction of sodium chloride in "salt-sensitive" patients (SSP). In such patients (84% of all examinees) with mild arterial hypertension moderate restriction of SC consumption causes a sufficient antihypertensive effect determined by considerable improvement of peripheral hemodynamic indices and improvement of myocardial pump function and contractility, and in patients with moderate and severe hypertension it potentiates an antihypertensive effect and influence of drug therapy on hemodynamics. In non-SSP moderate restriction in SC consumption was ineffective. A sufficient antihypertensive effect in them resulted from the use of drug therapy at higher dosage than in SSP.
共对50例I-II期原发性高血压患者进行了研究，以探讨“盐敏感”患者（SSP）适度限制氯化钠摄入时外周和心内血流动力学及心肌收缩性的变化。在这类患者（占所有受检者的84%）中，轻度动脉高血压患者适度限制氯化钠摄入可产生足够的降压效果，这表现为外周血流动力学指标显著改善、心肌泵功能和收缩性提高；而在中度和重度高血压患者中，适度限制氯化钠摄入可增强降压效果以及药物治疗对血流动力学的影响。在非盐敏感患者中，适度限制氯化钠摄入无效。他们通过使用比盐敏感患者更高剂量的药物治疗才产生了足够的降压效果。
