Kukes V G, Ignat'ev V G, Pavlova L I, Rumiantsev A S, Pavlov S S, Privalov A N, Chil'tsov V V
Klin Med (Mosk). 1996;74(2):20-3.
Corinfar-retard as a base of different combinations with triampur, Cordanum, Capoten were studied in 52 patients with stable arterial hypertension (systolic pressure > 180 mm Hg, diastolic pressure > 105 mm Hg). In the above combinations pharmacokinetics of corinfar-retard did not change. Good response was noted in corinfar-retard combination with Cordanum in patients with moderate hemodynamic changes, hypertonicity of sympathoadrenal system, tachycardia. In patients with impaired myocardial contractility, elevated total peripheral vascular resistance, noticeable hypotensive effects was registered in combination with triampur. The absence of hypotensive effect in the above combination required the addition of Capoten which was absolutely indicated in patients with stable increase in plasma renin activity.
对52例稳定型动脉高血压患者（收缩压>180 mmHg，舒张压>105 mmHg）研究了缓释可力丁与曲帕胺、可多胺、卡托普利不同组合的情况。在上述组合中，缓释可力丁的药代动力学未发生改变。在血流动力学变化中等、交感肾上腺系统亢进、心动过速的患者中，缓释可力丁与可多胺组合显示出良好疗效。在心肌收缩力受损、总外周血管阻力升高的患者中，与曲帕胺组合有明显的降压作用。上述组合中无降压作用时需加用卡托普利，这对血浆肾素活性持续升高的患者绝对适用。
