Changzhou Children's Hospital, Changzhou, Jiangsu, PR China.
PLoS One. 2019 Feb 8;14(2):e0212195. doi: 10.1371/journal.pone.0212195. eCollection 2019.
To study the short-term effects of a single-dose chloral hydrate on neonatal auditory perception by measuring auditory event-related potentials (aERPs).
Thirty-nine full-term neonates, aged 2-28 days and weighing 2980-4350 g, were divided into two groups including a chloral hydrate group (CH group, n = 17) and a non-chloral hydrate control group (non-CH group, n = 22). The CH group was given single-dose chloral hydrate (30 mg/kg) orally before aERPs measurement. An auditory oddball paradigm was used to elicit aERPs. P2 and N2 components of the ERP were recorded from electrodes at the Fz and Cz locations, and the areas under their curves (P2 and N2 areas) were calculated for the comparison between two groups.
Significant differences was found in the P2 area between the two groups at Fz and Cz (Fz: F (1,37) = 487.75, P < 0.05; Cz: F (1,37) = 1465.94, P < 0.05). Similarly, significant difference was also in the N2 area between the two groups at both locations (Fz: F(1,37) = 153.38, P < 0.05; Cz: F(1,37) = 798.42, P < 0.05).
A single-dose of chloral hydrate impacts neonatal auditory perception in the short-term. Long-term effects will also be studied in future.
通过测量听觉事件相关电位（aERPs）来研究氯醛合 1 剂单次剂量对新生儿听觉感知的短期影响。
39 例胎龄 2-28 天、体重 2980-4350g 的足月新生儿分为氯醛合 1 剂组（CH 组，n=17）和非氯醛合 1 剂对照组（非-CH 组，n=22）。CH 组在进行 aERPs 测量前口服给予单剂量氯醛合 1 剂（30mg/kg）。采用听觉Oddball 范式诱发 aERPs。记录 Fz 和 Cz 电极处 ERP 的 P2 和 N2 成分，并计算其曲线下面积（P2 和 N2 面积），以比较两组之间的差异。
两组在 Fz 和 Cz 处的 P2 面积有显著差异（Fz：F（1,37）=487.75，P<0.05；Cz：F（1,37）=1465.94，P<0.05）。同样，两组在两个部位的 N2 面积也有显著差异（Fz：F（1,37）=153.38，P<0.05；Cz：F（1,37）=798.42，P<0.05）。
氯醛合 1 剂单次剂量对新生儿听觉感知有短期影响。未来还将研究其长期影响。
