National Institute for Health and Welfare (THL), Finnish Office for Health Care Technology Assessment (FinOHTA), Helsinki, Finland.
Early Hum Dev. 2011 Feb;87(2):89-95. doi: 10.1016/j.earlhumdev.2010.11.009. Epub 2010 Dec 7.
auditory event-related potentials (AERPs) can be used as indices of neural information processing. Altered AERPs have been reported in children and young adults with frontal lobe infarction.
to test the hypothesis that perinatal brain injury affects cortical auditory processing.
we assessed AERPs at term, 6 and 12months of age in preterm infants [n=9, median gestational age (GA) 27.9, range 23.9-30.0wk], term infants with perinatal intracerebral hemorrhage (ICH) [n=5, GA 40.3, range 37.4-42.3wk], and term infants with perinatal asphyxia [n=4, GA 39.4, range 37.9-40.3wk]. Healthy preterm (n=16) and term infants (n=22) served as controls. A harmonic tone of 500-Hz frequency was used as standard and of 750-Hz as deviant stimulus. Mean AERP amplitudes were calculated over 100ms periods from 50 to 350ms. The developmental outcome was followed until 2years of age.
the term ICH (p=0.012) and asphyxia (p=0.0016) group had smaller or more negative responses to the deviant, resulting in smaller or more negative MMR amplitudes than those of the controls. The preterm ICH group did not differ significantly from their preterm born controls. MMR varied in all patient groups and was not associated with adverse outcome.
AERP alterations suggest that perinatal cerebral insults affect cortical auditory processing.
听觉事件相关电位（AERPs）可用作神经信息处理的指标。已有研究报道额叶梗死患儿和青年的 AERPs 发生改变。
检验脑损伤影响皮质听觉处理的假设。
我们在早产儿（n=9，中位胎龄 27.9 周，范围 23.9-30.0 周）、围产期颅内出血（ICH）的足月儿（n=5，胎龄 40.3 周，范围 37.4-42.3 周）和围产期窒息的足月儿（n=4，胎龄 39.4 周，范围 37.9-40.3 周）中，分别于足月、6 个月和 12 个月龄时检测 AERPs。正常早产儿（n=16）和足月儿（n=22）作为对照组。500-Hz 频率的谐波音作为标准，750-Hz 作为变异刺激。在 50-350ms 的 100ms 周期内计算平均 AERP 幅度。随访发育结果至 2 岁。
ICH 组（p=0.012）和窒息组（p=0.0016）对变异刺激的反应较小或更负，导致其 MMR 幅度较小或更负，与对照组相比有显著差异。ICH 组早产儿与同龄早产儿对照组无显著差异。MMR 在所有患者组中均存在差异，与不良结局无关。
AERP 改变提示围产期脑损伤影响皮质听觉处理。
