Wenzhou Medical University, Chashan University Park, Wenzhou, 325035, China; Department of Ophthalmology, The Affiliated Second Hospital of Wenzhou Medical University, #109 Xueyuan West Road, Wenzhou 325027, China.
Wenzhou Medical University, Chashan University Park, Wenzhou, 325035, China.
Regul Toxicol Pharmacol. 2019 Apr;103:189-195. doi: 10.1016/j.yrtph.2019.02.002. Epub 2019 Feb 5.
Keratinocyte growth factor -2 promotes corneal repair. Its mechanism of action involves regulating regeneration and migration of corneal cells, as well as activating corneal limbal stem cells. However, KGF-2 being a carcinogenic growth factor and its potential adverse effect in over dosage long-term treatment had not yet been reported. In this study, we used New Zealand white rabbits to study possible toxic effects of ocular administration of recombinant human keratinocyte growth factor-2 eye drops. Animals in the medium- and high-dose groups had some ocular irritant reactions during the course of drug administration; however this reaction was harmless to the cornea and it ended up when administration was stopped. Serum biochemistries were largely unaffected by treatment. Pathological examinations were unremarkable. We found that over-dosed administration of these eye drops caused some ocular irritation, but this irritant reaction was harmless to the eye, and it reversed after the drug was stopped. There were no apparent systemic effects of the drug.
角质细胞生长因子-2 可促进角膜修复。其作用机制涉及调节角膜细胞的再生和迁移，以及激活角膜缘干细胞。然而，KGF-2 是一种致癌生长因子，其在过量长期治疗中的潜在不良反应尚未报道。在这项研究中，我们使用新西兰白兔研究了重组人角质细胞生长因子-2 滴眼液眼部给药的可能毒性作用。中、高剂量组动物在药物给药过程中出现一些眼部刺激性反应；然而，这种反应对角膜无害，当停止给药时反应就会结束。血清生化指标受治疗影响不大。病理检查无明显异常。我们发现，这些滴眼液的超剂量给药会引起一些眼部刺激，但这种刺激性反应对眼睛无害，停药后即可逆转。药物没有明显的全身作用。
