Wang Xiaoke, Chen Yang, Wu Xiujuan, Zhang Hongliang
Department of Neurosurgery, the Second Hospital of Jilin University, Jilin University, Changchun, China.
Department of Neurology, the First Hospital of Jilin University, Jilin University, Changchun, China.
World Neurosurg. 2019 May;125:117-122. doi: 10.1016/j.wneu.2019.01.155. Epub 2019 Feb 5.
Inflammatory myofibroblastic tumor (IMT) is an indolent tumor mainly affecting children and young adults. As a rare mesenchymal tumor with unknown etiology and pathogenesis, IMT has a predilection for the lung and abdominopelvic region. Previous literature featuring IMT in the central nervous system (IMT-CNS) is rare. The clinical symptoms and radiologic features of IMT-CNS are not specific; therefore, the diagnosis is predominately based on the histopathologic and immunohistochemical analysis of the specimen.
We herein present a case of a 21-year-old woman who complained of bilateral blurred vision for 15 days. Head magnetic resonance imaging demonstrated a round-shaped and irregular lesion located in the right frontal lobe. The boundary of the lesion was clear, and the lesion was homogeneously enhanced. Peripheral edema of the lesion was observed, and the mass effect was obvious. Supratentorial craniotomy tumor resection was performed. Histopathologic and immunohistochemical analysis revealed IMT, which had negative expression of anaplastic lymphoma kinase.
Remission of her symptoms was observed, and no recurrence was recorded during a 6-month follow-up.
炎性肌纤维母细胞瘤（IMT）是一种主要影响儿童和年轻人的惰性肿瘤。作为一种病因和发病机制不明的罕见间叶性肿瘤，IMT好发于肺和腹盆腔区域。以往关于中枢神经系统炎性肌纤维母细胞瘤（IMT-CNS）的文献较少。IMT-CNS的临床症状和影像学特征不具有特异性；因此，诊断主要基于标本的组织病理学和免疫组织化学分析。
我们在此报告一例21岁女性，她主诉双侧视力模糊15天。头部磁共振成像显示右额叶有一个圆形不规则病变。病变边界清晰，呈均匀强化。观察到病变周围有水肿，占位效应明显。进行了幕上开颅肿瘤切除术。组织病理学和免疫组织化学分析显示为IMT，间变性淋巴瘤激酶呈阴性表达。
观察到她的症状缓解，在6个月的随访期间未记录到复发。
