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颅内炎性肌纤维母细胞瘤:文献综述及1例误诊为听神经瘤的罕见病例

Intracranial Inflammatory Myofibroblastic Tumor: A Literature Review and a Rare Case Misdiagnosed as Acoustic Neuroma.

作者信息

Zhou Le, Pan Wanqian, Huang Renjun, Lu Ziwei, You Zhiqun, Li Yonggang

机构信息

Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215000, China.

Department of Cardiology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, China.

出版信息

Diagnostics (Basel). 2023 Aug 22;13(17):2725. doi: 10.3390/diagnostics13172725.

Abstract

Inflammatory myofibroblastic tumor (IMT) stands as a rare neoplasm, initially documented by Bahadori and Liebow in 1973; however, its biological behavior and underlying pathogenesis continue to elude comprehensive understanding. Throughout the years, this tumor has been designated by various alternative names, including pseudosarcomatoid myofibroblastoma, fibromyxoid transformation, and plasma cell granuloma among others. In 2002, the World Health Organization (WHO) officially classified it as a soft tissue tumor and designated it as IMT. While IMT primarily manifests in the lungs, the common clinical symptoms encompass anemia, low-grade fever, limb weakness, and chest pain. The mesentery, omentum, and retroperitoneum are subsequent sites of occurrence with intracranial involvement being exceedingly rare. Due to the absence of specific clinical symptoms and characteristic radiographic features, diagnosing intracranial inflammatory myofibroblastic tumor (IIMT) remains challenging. Successful instances of pharmacological treatment for IIMT indicate that surgery may not be the sole therapeutic recourse, thus underscoring the imperative of an accurate diagnosis and apt treatment selection to improve patient outcomes.

摘要

炎性肌纤维母细胞瘤(IMT)是一种罕见的肿瘤,最初由Bahadori和Liebow于1973年记录;然而,其生物学行为和潜在发病机制仍未得到全面了解。多年来,这种肿瘤有多种不同的名称,包括假肉瘤样肌纤维母细胞瘤、纤维黏液样变性、浆细胞性肉芽肿等。2002年,世界卫生组织(WHO)正式将其归类为软组织肿瘤,并命名为IMT。IMT主要发生于肺部,常见临床症状包括贫血、低热、肢体无力和胸痛。肠系膜、大网膜和腹膜后是其次好发部位,颅内受累极为罕见。由于缺乏特异性临床症状和特征性影像学表现,诊断颅内炎性肌纤维母细胞瘤(IIMT)仍具有挑战性。IIMT药物治疗成功的病例表明,手术可能不是唯一的治疗手段,因此强调准确诊断和恰当选择治疗方法以改善患者预后的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2863/10486536/7268e310ba4a/diagnostics-13-02725-g001.jpg

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