Sport and Exercise Medicine Division, Department of Medicine, University of Padova, Padova, Italy.
Laboratorio de Fisiologia e Bioquimica Experimental, Centro de Educacao Fisica e Deportos, Universidade Federal do Espirito Santo (UFES), Vitoria, Brazil.
Hematol Oncol. 2019 Aug;37(3):277-284. doi: 10.1002/hon.2576. Epub 2019 Mar 18.
Therapy of hematological malignancies lasts for long periods implicating various complications. The chemotherapy induces fatigue and forces bed rest. These features strongly contribute to a general impairment of the physical efficiency. Oppositely, an increase of physical exercise can prevent or reduce this weakening. Few trials examined the efficacy of an exercise in onco-hematological inpatients, during their hospitalization. Therefore, this study aimed to determine the feasibility of an inter-hospital intervention and the beneficial role of a tailored exercise program in the maintenance of the physical function in onco-hematological inpatients. The study included 42 patients, which were allocated in two groups. In the intervention group (IG) a tailored exercise protocol during patient's hospitalization was administered. Exercise protocol was focused on development of strength, balance control, and flexibility; sessions were directly performed in the patient's hospital room everyday for 15 to 30 minutes. Exercise was supervised by an exercise specialist and driven by a multimedia support. Control group (CG) remained physically inactive for all period of hospitalization. To examine the interaction between the two situations (T and T ) and the two groups (IG and CG) for all dependent variables, a 2 × 2 within-subjects contrasts model analysis of variance was applied. Within groups analysis displayed significant differences in grip and leg strength and in static balance control (P < 0.05) with medium to very large effect size. Results from this investigation showed that a tailored exercise protocol administered to hospitalized onco-hematological patients was feasible and efficient to promote the maintenance of their physical function, improving clinical best practice including exercise to the traditional treatment. Moreover, the magnitude of the difference between the IG and the CG underlined the importance to invite and stimulate patients to workout to preserve the physical function, counteracting side effects of chemotherapy treatments with a concurrent reduction in bed rest syndrome.
血液病恶性肿瘤的治疗需要长期进行，这涉及到各种并发症。化疗会引起疲劳，迫使患者卧床休息。这些特点严重影响了身体效率。相反，增加身体锻炼可以预防或减少这种削弱。很少有试验研究过在肿瘤血液病住院患者中进行锻炼的效果，因此，本研究旨在确定医院间干预的可行性，以及量身定制的锻炼计划在维持肿瘤血液病住院患者身体功能方面的有益作用。该研究纳入了 42 名患者，将他们分为两组。在干预组（IG）中，在患者住院期间给予了量身定制的锻炼方案。锻炼方案侧重于力量、平衡控制和灵活性的发展；每天在患者的病房直接进行 15 到 30 分钟的锻炼。锻炼由一名运动专家监督，并由多媒体支持驱动。对照组（CG）在整个住院期间都不进行身体活动。为了检验两种情况（T 和 T ）和两组（IG 和 CG）之间所有因变量的相互作用，应用了 2×2 被试内对比模型分析方差。组内分析显示，握力和腿部力量以及静态平衡控制方面存在显著差异（P<0.05），具有中到非常大的效应量。这项研究的结果表明，为住院的血液病患者制定的量身定制的锻炼方案是可行且有效的，可以促进他们的身体功能维持，改善包括锻炼在内的传统治疗方法的临床最佳实践。此外，IG 和 CG 之间的差异幅度强调了邀请和激励患者进行锻炼以保持身体功能的重要性，以对抗化疗治疗的副作用，同时减少卧床休息综合征。
