Department of Hematology and Oncology, Freiburg University Medical Center.
Ann Oncol. 2014 Feb;25(2):493-9. doi: 10.1093/annonc/mdt568.
Lymphoma patients undergoing therapy must cope with the side-effects of the disease itself, therapy and associated immobility. Peripheral neuropathy (PNP), loss of balance control and weakness not only diminishes patients' quality of life (QOL), it can also affect planning and the dosage of therapy. Exercise may enable patients to reverse these declines, improving their performance level and QOL.
We carried out a randomized, controlled trial, assigning 61 lymphoma patients either to a control group (CG; N=31) or to a 36-week intervention (IG; N=30), consisting of sensorimotor-, endurance- and strength training twice a week. Primary end point was QOL; secondary end points included movement coordination, endurance, strength and therapy-induced side-effects.
Intergroup comparison revealed improved QOL- (ΔT1-T0; P=0.03) and PNP-related deep sensitivity in the IG: 87.5% were able to reduce the symptom, compared with 0% in the CG (P<0.001). Significant differences in the change of balance control could be found between the groups, with the IG improving while the CG steadily declined (monopedal static ΔT3-T0; P=0.03; dynamic ΔT3-T0; P=0.007; perturbed mono-ΔT3-T0; P=0.009 and bipedal ΔT3-T0; P=0.006), failed attempts (monopedal static ΔT3-T0; P=0.02, dynamic ΔT3-T0; P<0.001and perturbed ΔT3-T0; P=0.006) and improved time to regain balance (ΔT3-T0; P=0.04). Moreover, the change in the aerobic performance level (ΔT3-T0; P=0.05) and additional amount of exercise carried out per week [metabolic equivalent (MET); P=0.02] differed significantly across groups.
Exercise, especially sensorimotor training, is a feasible and promising method to support cancer patients during therapy. It improves patients QOL, reduces restrictions from side-effects such as PNP and improves patients' balance control, physical performance level and mobility.
DRKS00003894.
淋巴瘤患者在接受治疗时必须应对疾病本身、治疗和相关活动受限带来的副作用。周围神经病变（PNP）、平衡控制丧失和虚弱不仅会降低患者的生活质量（QOL），还会影响治疗计划和剂量。运动可以使患者逆转这些下降，提高他们的运动水平和生活质量。
我们进行了一项随机对照试验，将 61 名淋巴瘤患者分为对照组（CG；N=31）或 36 周干预组（IG；N=30），每周进行两次感觉运动、耐力和力量训练。主要终点是生活质量；次要终点包括运动协调、耐力、力量和治疗引起的副作用。
组间比较显示，IG 的生活质量（ΔT1-T0；P=0.03）和 PNP 相关深度敏感性得到改善：87.5%的患者能够减轻症状，而 CG 中为 0%（P<0.001）。两组之间在平衡控制变化方面存在显著差异，IG 有所改善，而 CG 则稳步下降（单足静态ΔT3-T0；P=0.03；动态ΔT3-T0；P=0.007；受扰单足ΔT3-T0；P=0.009 和双足ΔT3-T0；P=0.006），失败尝试（单足静态ΔT3-T0；P=0.02，动态ΔT3-T0；P<0.001 和受扰ΔT3-T0；P=0.006）和平衡恢复时间的改善（ΔT3-T0；P=0.04）。此外，有氧运动水平的变化（ΔT3-T0；P=0.05）和每周进行的额外运动量[代谢当量（MET）；P=0.02]在组间差异显著。
运动，尤其是感觉运动训练，是一种支持癌症患者治疗期间的可行且有前途的方法。它可以提高患者的生活质量，减轻 PNP 等副作用的限制，改善患者的平衡控制、身体运动水平和活动能力。
DRKS00003894。
