College of Life Science, North China University of Science and Technology, Tangshan, 063210, China.
School of Public Health, North China University of Science and Technology, Tangshan, 063210, China.
BMC Med Genet. 2019 Feb 8;20(1):29. doi: 10.1186/s12881-019-0762-6.
Tumor necrosis factor superfamily member 15 (TNFSF15) is closely related to tumorigenesis and development. This study aimed to investigate the correlations between TNFSF15 polymorphisms and genetic susceptibility to lung cancer.
This case-control study included 209 small cell lung cancer patients (SCLC), 340 non- small cell lung cancer patients (NSCLC) and 460 health controls. TNFSF15-638 A > G and - 358 T > C polymorphisms were genotyped by polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) analysis. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated by unconditional logistic regression.
Our results showed that subjects carrying the TNFSF15-638GG genotype or -358CC genotype were more likely to develop SCLC (-638GG, OR = 1.84, 95%CI = 1.13-2.99; -358CC, OR = 2.44, 95%CI = 1.46-4.06), but not NSCLC (P > 0.05). In stratified analysis, -638GG genotype was related to SCLC among males (OR = 1.95, 95%CI = 1.09-3.45, P = 0.023) and older patients (OR = 2.93, 95%CI = 1.44-8.68, P = 0.006). However, -358CC genotype was associated with SCLC among females (OR = 8.42, 95%CI = 2.22-31.89, P = 0.002) and older subjects with OR (95%CI) of 11.04 (3.57-34.15) (P < 0.001). Moreover, TNFSF15 -358CC was linked with a higher risk of SCLC among non-smokers (OR = 2.54, 95%CI = 1.20-5.35, P = 0.015) but not among smokers (OR = 1.88, 95%CI = 0.92-3.84, P = 0.086).
These findings highlight the importance of TNFSF15 polymorphisms in the development of SCLC.
肿瘤坏死因子超家族成员 15（TNFSF15）与肿瘤的发生和发展密切相关。本研究旨在探讨 TNFSF15 多态性与肺癌遗传易感性的相关性。
这项病例对照研究纳入了 209 例小细胞肺癌（SCLC）患者、340 例非小细胞肺癌（NSCLC）患者和 460 名健康对照。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析方法检测 TNFSF15-638A>G 和-358T>C 多态性。采用非条件 logistic 回归估计比值比（OR）和 95%置信区间（95%CI）。
我们的结果表明，携带 TNFSF15-638 GG 基因型或-358 CC 基因型的个体更易患 SCLC（-638 GG，OR=1.84，95%CI=1.13-2.99；-358 CC，OR=2.44，95%CI=1.46-4.06），但与 NSCLC 无关（P>0.05）。在分层分析中，-638 GG 基因型与男性（OR=1.95，95%CI=1.09-3.45，P=0.023）和老年患者（OR=2.93，95%CI=1.44-8.68，P=0.006）的 SCLC 相关。然而，-358 CC 基因型与女性（OR=8.42，95%CI=2.22-31.89，P=0.002）和老年患者（OR（95%CI）为 11.04（3.57-34.15）（P<0.001）的 SCLC 相关。此外，TNFSF15-358 CC 与非吸烟者（OR=2.54，95%CI=1.20-5.35，P=0.015）的 SCLC 风险升高相关，而与吸烟者（OR=1.88，95%CI=0.92-3.84，P=0.086）无关。
这些发现强调了 TNFSF15 多态性在 SCLC 发生发展中的重要性。
