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血管内皮生长因子 -2578C > a 基因多态性与肺癌风险的关系：荟萃分析。

Relationship between vascular endothelial growth factor -2578C > a gene polymorphism and lung cancer risk: a meta-analysis.

机构信息

Department of Clinical Laboratory Medicine, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi Province, 530021, People's Republic of China.

出版信息

BMC Med Genet. 2020 Jan 29;21(1):17. doi: 10.1186/s12881-019-0938-0.

DOI:10.1186/s12881-019-0938-0

PMID:31996156

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6990500/

Abstract

BACKGROUND

Several reports were published on the relationship between the vascular endothelial growth factor (VEGF) -2578C > A gene polymorphism and lung cancer risk; however, the results are debatable. This meta-analysis was conducted to assess the relationship between VEGF -2578C > A gene polymorphism and lung cancer risk.

METHODS

The associated literatures were identified on the 1st of September 2018 from CBM-disc (China Biological Medicine Database) and PubMed.

RESULT

A total of 14 reports were recruited into our meta-analysis to assess the association between VEGF -2578C > A gene polymorphism and lung cancer susceptibility. There was a marked association between VEGF -2578C > A A allele / CC genotype and lung cancer risk in overall and Asian populations (overall populations: A allele: OR = 1.26, 95% CI: 1.08-1.46, P = 0.003; CC genotype: OR = 0.72, 95% CI: 0.54-0.95, P = 0.02; Asians: A allele: OR = 1.33, 95% CI: 1.15-1.55, P = 0.0002; CC genotype: OR = 0.68, 95% CI: 0.50-0.93, P = 0.01). However, VEGF -2578C > A gene polymorphism was not associated with the risk of lung cancer in Caucasians.

CONCLUSION

VEGF -2578C > A A allele / CC genotype is associated with the lung cancer susceptibility in Asians and in overall populations.

摘要

背景

已有多篇关于血管内皮生长因子（VEGF）-2578C＞A 基因多态性与肺癌风险之间关系的报告发表，但结果存在争议。本荟萃分析旨在评估 VEGF-2578C＞A 基因多态性与肺癌风险之间的关系。

方法

于 2018 年 9 月 1 日通过中国生物医学文献数据库（CBM-disc）和 PubMed 检索相关文献。

结果

共纳入 14 项研究评估 VEGF-2578C＞A 基因多态性与肺癌易感性的关系。在总体人群和亚洲人群中，VEGF-2578C＞A A 等位基因/CC 基因型与肺癌风险之间存在显著关联（总体人群：A 等位基因：OR=1.26，95%CI：1.08-1.46，P=0.003；CC 基因型：OR=0.72，95%CI：0.54-0.95，P=0.02；亚洲人群：A 等位基因：OR=1.33，95%CI：1.15-1.55，P=0.0002；CC 基因型：OR=0.68，95%CI：0.50-0.93，P=0.01）。然而，VEGF-2578C＞A 基因多态性与高加索人群肺癌风险无关。