Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
J Allergy Clin Immunol. 2019 Feb;143(2):453-457. doi: 10.1016/j.jaci.2018.12.991.
Currently, we have a poor understanding of why some food allergies are outgrown and others are not. Deciphering the immune basis of the natural resolution of food allergy will likely provide critical information for developing new therapies for the treatment of persistent food allergies. There are limited cohort studies that have followed children with food allergy over time, but information generated from such cohorts points to features of innate and adaptive immunity, as well as environmental differences (microbiome) that discriminate those with persistent versus transient food allergy. Studies from mouse models highlight the importance of novel subsets of memory B cells rather than plasma cells combined with antigen re-exposure and T-cell help in the maintenance of IgE. In this review we discuss these findings from human cohorts and experimental systems and discuss existing gaps in our knowledge.
目前，我们对于为什么有些食物过敏会自行消退，而有些则不会，还知之甚少。解析食物过敏自然缓解的免疫基础，可能为开发治疗持续性食物过敏的新疗法提供关键信息。目前仅有少数队列研究对食物过敏的儿童进行了长期随访，但这些队列研究提供的信息表明，固有和适应性免疫以及环境差异（微生物组）可以区分持续性和短暂性食物过敏。来自小鼠模型的研究强调了新型记忆 B 细胞亚群而非浆细胞的重要性，加上抗原再次暴露和 T 细胞辅助，有助于 IgE 的维持。在这篇综述中，我们讨论了来自人类队列和实验系统的这些发现，并讨论了我们知识中的现有空白。
